859027-30-8

• 常用中文名：4-(4-Boc-哌嗪-1-基-甲基)-2-三氟甲基苯胺
• 常用英文名：4-(4-BOC-PIPERAZIN-1-YL-METHYL)-2-TRIFLUOROMETHYLANILINE
• CAS号：859027-30-8
• 分子式：C₁₇H₂₄F₃N₃O₂
• 分子量：359.38700
• 发布时间：2018-12-24 14:54:47
• 更新时间：2025-08-25 13:29:32

名称

• 中文名: 4-(4-Boc-哌嗪-1-基-甲基)-2-三氟甲基苯胺
• 英文名: tert-butyl 4-[[4-amino-3-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate
• 英文别名: 1-Piperazinecarboxylicacid,4-[[4-amino-2-(trifluoromethyl)phenyl]methyl]-,1,1-dimethylethyl ester; 4-[[4-Amino-2-(Trifluoromethyl)Phenyl]Methyl]-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 4-(4-Boc-piperazin-1-yl-methyl)-2-trifluoromethylaniline; tert-butyl 4-(4-amino-3-(trifluoromethyl)benzyl)piperazine-1-carboxylate; 4-(4-amino-2-trifluoromethyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester; 4-(4-amino-2-trifluoromethyl-benzyl)-1-piperazinecarboxylic acid,1,1-dimethylethyl ester; tert-butyl 4-{[4-amino-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

物化性质

• 密度: 1.24g/cm3
• 沸点: 412.422ºC at 760 mmHg
• 分子式: C₁₇H₂₄F₃N₃O₂
• 分子量: 359.38700
• 闪点: 203.226ºC
• 精确质量: 359.18200
• PSA: 58.80000
• LogP: 3.79730
• 折射率: 1.525

合成路线

859027-32-0 ~% 859027-30-8

文献：Huang, Wei-Sheng; Metcalf, Chester A.; Sundaramoorthi, Raji; Wang, Yihan; Zou, Dong; Thomas, R. Mathew; Zhu, Xiaotian; Cai, Lisi; Wen, David; Liu, Shuangying; Romero, Jan; Qi, Jiwei; Chen, Ingrid; Banda, Geetha; Lentini, Scott P.; Das, Sasmita; Xu, Qihong; Keats, Jeff; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T.; Broudy, Marc I.; Russian, Karin; Zhou, Tianjun; Commodore, Lois; Narasimhan, Narayana I.; Mohemmad, Qurish K.; Iuliucci, John; Rivera, Victor M.; Dalgarno, David C.; Sawyer, Tomi K.; Clackson, Tim; Shakespeare, William C. Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4701 - 4719

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