1186195-60-7

• 常用中文名：3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐
• 常用英文名：MTEP (hydrochloride)
• CAS号：1186195-60-7
• 分子式：C₁₁H₉ClN₂S
• 分子量：236.721
• 相关类别： 研究领域 神经疾病
• 发布时间：2016-02-07 09:45:53
• 更新时间：2024-01-05 17:59:52
• MTEP盐酸盐是非竞争性的mGlu5拮抗剂，IC50和Ki分别为5 nM和16 nM。

名称

• 中文名: 3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐
• 英文名: 2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole,hydrochloride
• 英文别名: 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride (1:1); CS-1249; MTEP hydrochloride; Pyridine, 3-[2-(2-methyl-4-thiazolyl)ethynyl]-, hydrochloride (1:1); 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride; MTEP hydrochloride||MTEP; MTEP (hydrochloride)

物化性质

• 分子式: C₁₁H₉ClN₂S
• 分子量: 236.721
• 精确质量: 236.017502
• PSA: 54.02000
• LogP: 3.04830
• 储存条件: 2-8℃

生物活性

• 描述: MTEP盐酸盐是非竞争性的mGlu5拮抗剂,IC50和Ki分别为5 nM和16 nM。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Nicolas Morin, Laurent Grégoire, Baltazar Gomez-Mancilla, et al. Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys. Neuropharmacology. 2010, 58 (7): 981-986

  [2]. Tom H. Johnston, Susan H. Fox, Matthew J. McIldowie, et al. Reduction of l-DOPA-Induced Dyskinesia by the Selective Metabotropic Glutamate Receptor 5 Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyri

  [3]. Bradbury MJ, Campbell U, Giracello D, et al. Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J Pharmacol Exp Ther. 2005 Apr;313(1):395-402.

  [4]. Klodzinska A, Tatarczyńska E, Chojnacka-Wójcik E et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacology. 2004 Sep;47(3):342-50.

  [5]. Brodkin J, Bradbury M, Busse C, et al. Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur J Neurosci. 2002 Dec;16(11):2241-4.