6296-45-3

• 常用中文名：Carbamic acid,(2-chloroethyl)nitroso-, ethyl ester (7CI,8CI,9CI)
• 常用英文名：Carbamic acid,(2-chloroethyl)nitroso-, ethyl ester (7CI,8CI,9CI)
• CAS号：6296-45-3
• 分子式：C₅H₉ClN₂O₃
• 分子量：180.59000
• 发布时间：2016-04-19 03:37:31
• 更新时间：2025-09-26 16:23:05

名称

• 英文名: ethyl N-(2-chloroethyl)-N-nitrosocarbamate
• 英文别名: TL 154; 2-Chloroethyl-N-nitrosourethane

物化性质

• 密度: 1.3g/cm3
• 沸点: 215.4ºC at 760 mmHg
• 分子式: C₅H₉ClN₂O₃
• 分子量: 180.59000
• 闪点: 84.1ºC
• 精确质量: 180.03000
• PSA: 58.97000
• LogP: 1.36510
• 折射率: 1.493
• 储存条件: 库房通风低温干燥,与食品原料分开储运

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EZ2100000 CHEMICAL NAME : Carbamic acid, (2-chloroethyl)nitroso-, ethyl ester CAS REGISTRY NUMBER : 6296-45-3 BEILSTEIN REFERENCE NO. : 1781530 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C5-H9-Cl-N2-O3 MOLECULAR WEIGHT : 180.61 WISWESSER LINE NOTATION : ON2OVM2G HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - alteration in gastric secretion TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 330 mg/m3/10M TOXIC EFFECTS : Behavioral - irritability Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6500 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - pleural effusion Skin and Appendages - dermatitis, other (after systemic exposure) TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/m3/10M TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 330 mg/m3/10M TOXIC EFFECTS : Behavioral - irritability Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 330 mg/m3/10M TOXIC EFFECTS : Behavioral - irritability Lungs, Thorax, or Respiration - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 500 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,175,1983

合成路线

6329-26-6 ~64% 6296-45-3

文献：Lown, J. William; Joshua, Alummoottil V.; McLaughlin, Larry W. Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 798 - 805

671-51-2 ~% 6296-45-3

文献：Kamiya,S. Chemical and Pharmaceutical Bulletin, 1972 , vol. 20, p. 2497 - 2500

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