23233-88-7

23233-88-7结构式

常用中文名：溴替尼持
常用英文名：brotianide
CAS号：23233-88-7
分子式：C₁₅H₁₀Br₂ClNO₂S
分子量：463.57100
相关类别：原料药抗肿瘤药替尼类抗肿瘤药
发布时间：2018-03-04 08:00:00
更新时间：2024-01-15 07:22:38
该品为抗肝片吸虫药，特别对肝片吸虫幼虫具有良好的驱虫效果。对急性感染肝片吸虫的4-8周龄幼虫减虫率为72-100%；对8-10周龄幼虫为97-100%。以亚急性肝片吸虫病6-10周龄幼虫灭虫率为96%以上；10周龄幼虫减虫率几乎达100%。对慢性肝片吸虫病10周龄幼虫和成虫减虫率为89-93%。对严重感染的病畜以10.5mg/kg剂量，经药二次，间隔30d，减虫率可达995。对暴发性的严重感染病畜，为彻底清除幼虫起见，必须在30天后重复治疗一次，经治疗的羊乳量平均可增加19%，对乳质无影响。对枝腔吸虫的效果，按2.5-10mg/kg给药，减虫率可达95%。该品毒副作用小，耐受良好。绵羊口服LD50为40-45mg/kg。治疗指数为4-7。由于该药毒性低，故孕畜、新分娩畜、泌乳畜和羔羊均可使用。

中文名	溴替尼持
英文名	[2-bromo-6-[(4-bromophenyl)carbamothioyl]-4-chlorophenyl] acetate
中文别名	2-乙酰氧基-3-溴-5-氯-N-4'溴苯基硫代苯甲酰胺
英文别名	Brotianida [INN-Spanish] 2-acetoxy-3-bromo-5-chloro-N-(4'-bromophenyl)-thionobenzamide 2-Brom-6-(4-bromphenylthiocarbamoyl)-4-chlorphenylacetat BAY-VA 4059 3,4'-Dibromo-5-chlorothiosalicylanilide acetate (ester) Brotianide Brotianidum [INN-Latin] EINECS 245-505-9 Dirian 2-Acetoxy-3-bromo-5-chloro-N-(p-bromophenyl)-thiobenzamide FB a 4059

密度	1.795g/cm3
沸点	514.1ºC at 760mmHg
熔点	181°C
分子式	C₁₅H₁₀Br₂ClNO₂S
分子量	463.57100
闪点	264.7ºC
精确质量	460.84900
PSA	70.42000
LogP	5.65090
蒸汽压	1.11E-10mmHg at 25°C
折射率	1.699
储存条件	库房通风低温干燥,与食品原料类分开存放
分子结构	1、摩尔折射率：99.70 2、摩尔体积（cm³/mol）：258.1 3、等张比容（90.2K）：726.7 4、表面张力（dyne/cm）：62.8 5、极化率（10-24cm3）：39.52
计算化学	1.疏水参数计算参考值（XlogP）:5.1 2.氢键供体数量:1 3.氢键受体数量:3 4.可旋转化学键数量:4 5.互变异构体数量:2 6.拓扑分子极性表面积70.4 7.重原子数量:22 8.表面电荷:0 9.复杂度:418 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1性状：结晶。 2熔点：181℃。 3溶解性：可溶于有机溶剂。

毒理学数据:

本品毒副作用小,耐受良好。绵羊口服LD50为40~45mg/kg。由于该药毒性低,故孕畜、新分娩畜、哺乳畜和羔羊均可使用。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN8230000

CHEMICAL NAME :: Salicylanilide, 3,4'-dibromo-5-chlorothio-, acetate (ester)

CAS REGISTRY NUMBER :: 23233-88-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H10-Br2-Cl-N-O2-S

MOLECULAR WEIGHT :: 463.59

WISWESSER LINE NOTATION :: QVR DG BE FYUS&MR DE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

海关编码	2930909090

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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