92-62-6

• 常用中文名：吖啶-3,6-二胺
• 常用英文名：Proflavine
• CAS号：92-62-6
• 分子式：C₁₃H₁₁N₃
• 分子量：209.24700
• 相关类别： 生物化工 氨基酸及其衍生物 缬氨酸类衍生物
• 发布时间：2016-07-12 03:41:31
• 更新时间：2024-01-06 11:13:58
• 丙氨酸是一种吖啶染料,是一种已知的DNA插层剂。抗菌剂[1]。普罗拉芬对Kir3起到了毛孔阻滞剂的作用。2.丙氨酸是Kir3的潜在先导化合物。2-相关神经系统疾病[2]。

名称

• 中文名: 吖啶-3,6-二胺
• 英文名: 3,6-diaminoacridine
• 英文别名: 3,6-Diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile; 3,6-Diamino-5-cyan-1-methyl-1H-pyrazolo<3,4-b>pyridin; acridine-3,6-diamine; 3,6-Acridinediamine

物化性质

• 密度: 1.346 g/cm3
• 沸点: 506.9ºC at 760 mmHg
• 熔点: 260ºC
• 分子式: C₁₃H₁₁N₃
• 分子量: 209.24700
• 闪点: 292.9ºC
• 精确质量: 209.09500
• PSA: 64.93000
• LogP: 3.71480
• 外观性状: 橙色至棕色粉末
• 折射率: 1.833
• 储存条件: 存放于惰性气体之中;避免空气
• 水溶解性: 水溶性：可溶；可溶于：乙醇,二甲基甲酰胺；不溶：苯,乙醚

生物活性

• 描述: 丙氨酸是一种吖啶染料,是一种已知的DNA插层剂。抗菌剂[1]。普罗拉芬对Kir3起到了毛孔阻滞剂的作用。2.丙氨酸是Kir3的潜在先导化合物。2-相关神经系统疾病[2]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

  [2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28.

  [3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AR8670000 CHEMICAL NAME : Acridine, 3,6-diamino- CAS REGISTRY NUMBER : 92-62-6 BEILSTEIN REFERENCE NO. : 0166050 LAST UPDATED : 199806 DATA ITEMS CITED : 42 MOLECULAR FORMULA : C13-H11-N3 MOLECULAR WEIGHT : 209.27 WISWESSER LINE NOTATION : T C666 BNJ EZ MZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 11111 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes TYPE OF TEST : Specific locus test TYPE OF TEST : DNA inhibition MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 13500 nmol/L REFERENCE : ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 67,127,1965 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6466 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 621 (estimated)

安全

• 海关编码: 2933990090

合成路线

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%