87238-52-6

• 常用中文名：Ritipenemacoxil
• 常用英文名：Ritipenemacoxil
• CAS号：87238-52-6
• 分子式：C₁₃H₁₆N₂O₈S
• 分子量：360.34000
• 发布时间：2016-10-25 01:16:31
• 更新时间：2024-01-09 12:25:03

名称

• 英文名: Acetoxymethyl (5R,6S)-3-[(carbamoyloxy)methyl]-6-[(1R)-1-hydroxye thyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
• 英文别名: Ritanserinum [Latin]; Ritanserine; Ritanserinum; Ritanserine [French]; ritanserin; Ritanserina; risperidone; Acetoxymethyl(5R,6S)-2-carbamoyloxy-methyl-6-[1(R)hydroxyethyl]penem-3-carboxylate; Tiserton; Ritanserina [Spanish]

物化性质

• 密度: 1.57g/cm3
• 沸点: 656ºC at 760 mmHg
• 分子式: C₁₃H₁₆N₂O₈S
• 分子量: 360.34000
• 闪点: 350.6ºC
• 精确质量: 360.06300
• PSA: 171.75000
• 折射率: 1.62

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XI0192000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-6- (1-hydroxyethyl)-7-oxo-, (acetyloxy)methyl ester, (5R-(5-alpha,6-alpha(R*)))- CAS REGISTRY NUMBER : 87238-52-6 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C13-H16-N2-O8-S MOLECULAR WEIGHT : 360.37 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 23(Suppl C),129,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4363 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 23(Suppl C),129,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 91 gm/kg/26W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Metabolism (Intermediary) - lipids including transport REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 23,34,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 42 gm/kg/2W-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 23(Suppl C),129,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 73 gm/kg/26W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Kidney, Ureter, Bladder - changes in bladder weight REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 23,34,1995

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