917251-86-6

• 常用中文名：8-溴-3-(三氟甲基)喹啉
• 常用英文名：8-Bromo-3-(trifluoromethyl)quinoline
• CAS号：917251-86-6
• 分子式：C₁₀H₅BrF₃N
• 分子量：276.053
• 发布时间：2018-09-10 14:19:17
• 更新时间：2025-08-25 17:45:42

名称

• 中文名: 8-溴-3-(三氟甲基)喹啉
• 英文名: 8-Bromo-3-(trifluoromethyl)quinoline
• 英文别名: 8-Bromo-3-(trifluoromethyl)quinoline; y6499; Quinoline, 8-bromo-3-(trifluoromethyl)-; 8-bromo-3-(trifluoromethyl)-quinoline

物化性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 301.3±37.0 °C at 760 mmHg
• 分子式: C₁₀H₅BrF₃N
• 分子量: 276.053
• 闪点: 136.0±26.5 °C
• 精确质量: 274.955750
• PSA: 12.89000
• LogP: 3.48
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.573
• 储存条件: 2-8℃，干燥

合成路线

917251-85-5 81290-20-2 ~% 917251-86-6

文献：US2007/27160 A1, ; Page/Page column 53 ; US 20070027160 A1

25199-76-2 ~0% 917251-86-6 1239462-41-9

文献：ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely Patent: WO2010/91310 A1, 2010 ; Location in patent: Page/Page column 148 ; WO 2010/091310 A1

917251-85-5 10112-11-5 ~32% 917251-86-6

文献：Childers, Wayne E.; Havran, Lisa M.; Asselin, Magda; Bicksler, James J.; Chong, Dan C.; Grosu, George T.; Shen, Zhongqi; Abou-Gharbia, Magid A.; Bach, Alvin C.; Harrison, Boyd L.; Kagan, Natasha; Kleintop, Teresa; Magolda, Ronald; Marathias, Vasilios; Robichaud, Albert J.; Sabb, Annmarie L.; Zhang, Mei-Yi; Andree, Terrance H.; Aschmies, Susan H.; Beyer, Chad; Comery, Thomas A.; Day, Mark; Grauer, Steven M.; Hughes, Zoe A.; Rosenzweig-Lipson, Sharon; Platt, Brian; Pulicicchio, Claudine; Smith, Deborah E.; Sukoff-Rizzo, Stacy J.; Sullivan, Kelly M.; Adedoyin, Adedayo; Huselton, Christine; Hirst, Warren D. Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4066 - 4084

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