287930-75-0

• 常用中文名：(2R)-4-苄基-2-[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]吗啉-3-酮
• 常用英文名：(2R)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one
• CAS号：287930-75-0
• 分子式：C₂₁H₁₉F₆NO₃
• 分子量：447.371
• 发布时间：2019-01-09 22:46:16
• 更新时间：2025-08-25 07:07:47

名称

• 中文名: (2R)-4-苄基-2-[(1R)-1-[3,5-双(三氟甲基)苯基]乙氧基]吗啉-3-酮
• 英文名: (2R)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one
• 中文别名: 阿瑞匹坦中间体; 阿瑞匹坦主链
• 英文别名: (2R)-4-Benzyl-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-morpholinone; 3-Morpholinone, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(phenylmethyl)-, (2R)-; (R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholin-3-one; QC-589; (2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE; Aprepitant Impurity 29

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 457.4±45.0 °C at 760 mmHg
• 分子式: C₂₁H₁₉F₆NO₃
• 分子量: 447.371
• 闪点: 230.4±28.7 °C
• 精确质量: 447.126923
• PSA: 38.77000
• LogP: 4.80
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.523
• 储存条件: 室温，干燥

合成路线

327623-36-9 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

368-63-8 502537-07-7 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

104-63-2 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

30071-93-3 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

110843-90-8 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

287930-73-8 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

368-63-8 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

502536-97-2 ~% 287930-75-0

文献：Brands, Karel M. J.; Payack, Joseph F.; Rosen, Jonathan D.; Nelson, Todd D.; Candelario, Alexander; Huffman, Mark A.; Zhao, Matthew M.; Li, Jing; Craig, Bridgette; Song, Zhiguo J.; Tschaen, David M.; Hansen, Karl; Devine, Paul N.; Pye, Philip J.; Rossen, Kai; Dormer, Peter G.; Reamer, Robert A.; Welch, Christopher J.; Mathre, David J.; Tsou, Nancy N.; McNamara, James M.; Reider, Paul J. Journal of the American Chemical Society, 2003 , vol. 125, # 8 p. 2129 - 2135

上下游产品

上游产品  6
327623-36-9 368-63-8 104-63-2 30071-93-3
110843-90-8 287930-73-8
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