26833-86-3

• 常用中文名：异三尖杉酯碱
• 常用英文名：Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate]
• CAS号：26833-86-3
• 分子式：C₂₈H₃₇NO₉
• 分子量：531.59500
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-06-08 19:48:51
• 更新时间：2024-01-16 14:52:40
• 异三尖杉酯碱是一种天然生物碱,可从三尖杉中提纯。异三尖杉酯碱能抑制癌症细胞增殖和迁移,诱导癌症细胞凋亡。异三尖杉酯碱可用于癌症研究[1][2]。

名称

• 中文名: 异三尖杉酯碱
• 英文名: Isoharringtonine
• 英文别名: iso-harringtonine

物化性质

• 密度: 1.35g/cm3
• 沸点: 632.5ºC at 760mmHg
• 熔点: 70.75°C
• 分子式: C₂₈H₃₇NO₉
• 分子量: 531.59500
• 精确质量: 531.24700
• PSA: 123.99000
• LogP: 1.98440
• 蒸汽压: 7.21E-17mmHg at 25°C
• 折射率: 1.607

生物活性

• 描述: 异三尖杉酯碱是一种天然生物碱,可从三尖杉中提纯。异三尖杉酯碱能抑制癌症细胞增殖和迁移,诱导癌症细胞凋亡。异三尖杉酯碱可用于癌症研究[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Lee JH, et al. Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway. Biomolecules. 2020 Nov 6;10(11):1521.

  [2]. Chen W, et al. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. Biomed Pharmacother. 2018 Jul;103:435-442.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NR2935500 CHEMICAL NAME : Isoharringtonine CAS REGISTRY NUMBER : 26833-86-3 LAST UPDATED : 198909 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C28-H37-N-O9 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27950 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 14600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 26110 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 13200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988