188174-64-3

• 常用中文名：棕榈酰辅酶A
• 常用英文名：Palmitoyl coenzyme A lithium
• CAS号：188174-64-3
• 分子式：C₃₇H₆₅LiN₇O₁₇P₃S
• 分子量：1011.876
• 相关类别： 研究领域 代谢疾病
• 发布时间：2022-04-01 14:16:31
• 更新时间：2025-08-24 21:02:06
• 棕榈酰辅酶A锂盐 是与辅酶A共价连接的长链脂肪酸（C16）。棕榈酸酯与棕榈酰辅酶A锂盐的共价结合是多种细胞和病毒蛋白中的常见现象，起着重要作用促进膜结合。通过棕榈酰辅酶进行棕榈酰化锂盐也可能是延长或增强G蛋白信号传导的一般机制。棕榈酰辅酶A锂盐 也已用于显微注射new卵，以研究柠檬酸合酶抑制在卵活化中的作用。棕榈酰辅酶A锂盐 也称为辅酶A（锂盐），十六烷酰基辅酶A和正十六烷酰基辅酶A. Palmitoyl coenzyme A lithium salt is a long chain fatty acid (C16) that is covalently linked to Coenzyme A. The covalent attachment of palmitate to Palmitoyl coenzyme A lithium salt is a common occurrence in a wide variety of cellular and viral proteins, playing a role in promoting membrane binding. Palmitoylation through Palmitoyl coenzyme A lithium salt may also be a general mechanism for prolonging or potentiating G-protein signaling. Palmitoyl coenzyme A lithium salt has also been used for microinjecting newt eggs, to study the effect of citrate synthase inhibition in egg activation. Palmitoyl coenzyme A lithium salt is also known as Coenzyme A (lithium salt), Hexadecanoyl coenzyme A, and n-Hexadecanoyl Coenzyme A.

名称

• 中文名: 棕榈酰辅酶A锂盐
• 英文名: Palmitoyl coenzyme A lithium salt
• 英文别名: Palmitoyl coenzyme A lithium salt; Palmitoyl coenzyme A lithium salt is also known as n-Hexadecanoyl Coenzyme A.; n-Hexadecanoyl Coenzyme A; Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[[2-[(1-oxohexadecyl)thio]ethyl]amino]propyl]amino]butoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate), lithium salt (1:1); Hexadecanoyl coenzyme A; MFCD01863103

物化性质

• 分子式: C₃₇H₆₅LiN₇O₁₇P₃S
• 分子量: 1011.876
• 精确质量: 1011.353027
• 外观性状: 固体
• 储存条件: -20°C储存
• 水溶解性: Soluble in water

生物活性

• 描述: 棕榈酰辅酶A锂是一种酰基辅酶A硫酯,可以通过肉碱穿梭系统运输到线粒体基质,并参与β-氧化。棕榈酰辅酶A锂也可用作鞘氨醇生物合成的底物[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
• 体外研究: 棕榈酰辅酶A锂(100μM)可逆抑制鸡肝细胞的乙酰辅酶A羧化酶活性,并与柠檬酸竞争,在体内脂肪酸合成的调节中具有重要作用[1]。线粒体中含量较高的棕榈酰辅酶A锂可减少ADP的进入,从而导致棕榈酰辅酸A对谷氨酸脱氢酶的抑制作用增强[2]。
• 参考文献:

  [1]. A G Goodridge, et al. Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate. J Biol Chem. 1972 Nov 10;247(21):6946-52.

  [2]. L A Fahien, et al. Regulation of glutamate dehydrogenase by palmitoyl-coenzyme A. Arch Biochem Biophys. 1981 Nov;212(1):247-53.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3