4013-72-3

• 常用中文名：叠氮烟酸甲酰
• 常用英文名：nicotinoyl azide
• CAS号：4013-72-3
• 分子式：C₆H₄N₄O
• 分子量：148.12200
• 相关类别： 无机化工 无机盐 氢化物、氮化物、叠氮化物 叠氮化物
• 发布时间：2018-03-12 08:00:00
• 更新时间：2025-08-27 10:53:04
• Nicotinoyl azide 能够形成高能中间体,能和腺苷或鸟苷形成C-8加合物。

名称

• 中文名: 叠氮烟酸甲酰
• 英文名: pyridine-3-carbonyl azide
• 中文别名: 叠氮基(吡啶-3-基)甲酮; 叠氮烟酰
• 英文别名: 3-pyridylcarbonyl azide; 3-pyridinecarboxylic acid azide; NICOTINOYL AZIDE; nicotynic acid azide; azido(pyridin-3-yl)methanone; pyridine-3-carboxylic acid azide; 3-Pyridinecarbonyl azide (9CI); Nicotinic acid azide; 3-Pyridinecarbonylazide

物化性质

• 分子式: C₆H₄N₄O
• 分子量: 148.12200
• 精确质量: 148.03900
• PSA: 79.71000
• LogP: 0.98486
• 储存条件: 2-8°C

生物活性

• 描述: Nicotinoyl azide 能够形成高能中间体,能和腺苷或鸟苷形成C-8加合物。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Chao Feng, et al. Light-activated chemical probing of nucleobase solvent accessibility inside cells. Nat Chem Biol. 2018 Mar;14(3):276-283.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QT3325000 CHEMICAL NAME : Nicotinoyl azide CAS REGISTRY NUMBER : 4013-72-3 LAST UPDATED : 199712 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C6-H4-N4-O MOLECULAR WEIGHT : 148.14 WISWESSER LINE NOTATION : T6NJ CVNNN HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 108,473,1956 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 166 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,692,1955

安全

• 海关编码: 2933399090

合成路线

553-53-7 ~77% 4013-72-3

文献：Adkinson, Dana K.; Magri, David C.; Pitters, Jason L.; Griffiths, Keith; Norton, Peter R.; Workentin, Mark S. Photochemistry and Photobiology, 2013 , vol. 89, # 5 p. 1020 - 1028

1120-90-7 201230-82-2 ~77% 4013-72-3

文献：Miloserdov, Fedor M.; Grushin, Vladimir V. Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3668 - 3672

1120-90-7 50-00-0 ~77% 4013-72-3

文献：Miloserdov, Fedor M.; McMullin, Claire L.; Belmonte, Marta Martinez; Benet-Buchholz, Jordi; Bakhmutov, Vladimir I.; Macgregor, Stuart A.; Grushin, Vladimir V. Organometallics, 2014 , vol. 33, # 3 p. 736 - 752

500-22-1 ~87% 4013-72-3

文献：Bose, D. Subhas; Reddy, A. V. Narsimha Tetrahedron Letters, 2003 , vol. 44, # 17 p. 3543 - 3545

59-67-6 ~88% 4013-72-3

文献：Kim, Joong-Gon; Jang, Doo Ok Synlett, 2008 , # 13 p. 2072 - 2074

20260-53-1 ~64% 4013-72-3

文献：Kinoyama, Isao; Taniguchi, Nobuaki; Toyoshima, Akira; Nozawa, Eisuke; Kamikubo, Takashi; Imamura, Masakazu; Matsuhisa, Akira; Samizu, Kiyohiro; Kawanimani, Eiji; Niimi, Tatsuya; Hamada, Noritaka; Koutoku, Hiroshi; Furutani, Takashi; Kudoh, Masafumi; Okada, Minoru; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 716 - 726

144223-30-3 ~78% 4013-72-3

文献：Katritzky, Alan R.; Widyan, Khalid; Kirichenko, Kostyantyn Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5802 - 5804

98277-31-7 ~% 4013-72-3

文献：Smushkevich, Yu. I.; Usorov, M. I. Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 11 p. 2210 - 2211 Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 11 p. 2450 - 2451

上下游产品

上游产品  7
553-53-7 59-67-6 20260-53-1 1120-90-7
201230-82-2 50-00-0 500-22-1
下游产品  10
39642-60-9 56700-70-0 583-08-4 98-92-0
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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%