70529-35-0

• 常用中文名：伊他格雷
• 常用英文名：Itazigrel
• CAS号：70529-35-0
• 分子式：C₁₈H₁₄F₃NO₂S
• 分子量：365.36900
• 发布时间：2018-08-04 09:22:48
• 更新时间：2024-01-03 11:34:40

名称

• 中文名: 伊他格雷
• 英文名: 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1,3-thiazole
• 英文别名: 4,5-bis(p-Methoxyphenyl)-2-(trifluoromethyl)thiazole; 2-Trifluormethyl-4,5-bis(p-methoxyphenyl)thiazole; Itazigrelum [Latin]; Itazogrel; ITAZIGREL; 4,5-bis-(4-methoxy-phenyl)-2-trifluoromethyl-thiazole; 2-Trifluormethyl-4,5-di-p-anisylthiazol

物化性质

• 密度: 1.285g/cm3
• 沸点: 400.3ºC at 760 mmHg
• 分子式: C₁₈H₁₄F₃NO₂S
• 分子量: 365.36900
• 闪点: 195.9ºC
• 精确质量: 365.07000
• PSA: 59.59000
• LogP: 5.51310
• 折射率: 1.547

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XJ2983000 CHEMICAL NAME : Thiazole, 4,5-bis(4-methoxyphenyl)-2-trifluoromethyl- CAS REGISTRY NUMBER : 70529-35-0 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H14-F3-N-O2-S MOLECULAR WEIGHT : 365.39 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4659726 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THHADQ Thrombosis and Haemostasis. (F.K. Schattauer Verlag, Postfach 104545, D-70040 Stuttgart, Germany) V.35- 1976- Volume(issue)/page/year: 46,26,1981

合成路线

27895-95-0 421-52-3 ~% 70529-35-0

文献：Rynbrandt, Ronald H.; Nishizawa, Edward E.; Balogoyen, Doris P.; Mendoza, A. Rene; Annis, Kathleen A. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1507 - 1510

15857-57-5 354-38-1 ~34% 70529-35-0

文献：Rynbrandt, R. H.; Nishizawa, E.- E.; Balogoyen, D. P.; Mendoza, A. R.; Annis, U. A. J. Med. Chem., 1981 , vol. 24, p. 1507 - 1510 View citing articles Show Details Gmelin Handbook: F: PerFHalOrg.SVol.1, 6.2.1.2, page 193 - 198 Show Details The Upjohn Co., Rynbrandt, R. H. Patent: DE2836742 , 1979 ; C.A., 1979 , vol. 91, p. 20490

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