85175-59-3

• 常用中文名：7,8-二甲氧基-3-(3-氯代丙基)-1,3-二氢-2H-3-苯并氮杂卓-2-酮
• 常用英文名：3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
• CAS号：85175-59-3
• 分子式：C₁₅H₁₈ClNO₃
• 分子量：295.761
• 发布时间：2018-12-15 17:23:44
• 更新时间：2026-08-08 15:51:18

名称

• 中文名: 7,8-二甲氧基-3-(3-氯丙基)-1,3-二氢-2H-3-苯并氮杂卓-2-酮
• 英文名: 3-(3-chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2-one
• 中文别名: 盐酸伊伐布雷定杂质28; 伊瓦布拉定杂质28; 盐酸伊伐布雷定侧链氯代物; 盐酸伊伐布雷定侧; 伊法布雷定中间体; 7,8-二甲氧基-3-(3-氯代丙基)-1,3-二氢-2H-3-苯并氮杂卓-2-酮(七元环); 7,8-二甲氧基-3-(3-氯代丙基)-1,3-二氢-2H-3-苯并氮杂卓-2-酮(伊伐布雷定杂质); 伊伐布雷定杂质64; 7,8-二甲氧基-3-(3-氯代丙基)-1,3-二氢-2H-3-苯并氮杂卓-2-酮 伊伐布雷定中间体; 伊伐布雷定杂质C; 伊伐布雷定侧链; 伊伐布雷定的中间体; 3-(3-氯代丙基)-1,3-二氢-7,8-二甲氧基-2H-3-苯卓-2-酮; 3-二氢-7; 伊伐布雷定杂质F; (FOR IVABRADINE) 3-(3-氯丙基)-1,3-二氢-7,8-二甲氧基-2H-3-苯并氮杂环庚二烯-2-酮 (伊伐布雷定中间体); 伊伐布雷定中间体二; 伊伐布雷定侧链/伊伐布雷定侧链氯代物/7,8-二甲氧基-3-(3-氯代丙基)-1,3-二氢-2H-3-苯并氮杂卓-2-酮; 8-二甲氧基-2H-3-苯并氮杂环庚二烯-2-酮; 3-(3-氯丙基)-1; 盐酸伊伐布雷定侧链; 伊伐布雷定相关化合物4; 3-(3-氯丙基)-1,3-二氢-7,8-二甲氧基-2H-3-苯并氮杂环庚二烯-2-酮
• 英文别名: Ivabradin-1; Ivabradine Impurity 8; 8-diethyl-1H-benzo[d] azin-2 (3H)-one; (S)-3,3'-((((3,4-dimethoxybicyclo[4.2.0]octa-1,2,4-trien-7-yl)methyl)azanediyl)bis(propane-3,1-diyl))bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azin-2-one); 7,8-dimethoxy-3- (3-chloropropyl) - 1,3-dihydro-2h-3-benzoazine-2-one; 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazin-2-onezazin-2-one; 3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2h-3-benzazepin-2-one; 3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3-Benzazin-2-one(For Ivabradine); xy-1,3-dihydro-2H-3-benzazin; 3-(3-Chloropropyl)-7,8-diMethoxy-1H-3-benzazin-2(3H)-one; ,3-dihydro-benzo[d]azepin-2-one; AZIN-2 (3H) - (Z) -3- (3-chloropropyl) -7, 8-diethyl-1H - benzo [D] azin-2 (3H); 7,8-dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazepin-2-one; (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azin-2 (3H); (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azin-2 (3H)-one; Ivabradine chloro Impurity 3-(3-chloropropy)-7,8-dimethoxy-1,3-dihydro-2H- benzo[d]azin-2-one; 2-one; 7,8-dimethoxy-3-(3 -chloropropyl) - 1,3- dihydro-2h -3- benzoazapine-2one; 8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazin-2-one; 1-(7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl)-3-chloro-propane; Ivabradine Impurity 64; 3-(3-chloropropyl)-7,8-diMethoxy-1H-benzo[d]azin-2(3H)-one; 3-(3-Chloro-propyl)-7,8-dimethoxy-1; 3-(3-chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azin-2-one; 2H-3-Benzazepin-2-one,3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy; Ivabradine Impurity c; 3-(3-chloropropyl)-7,8-dimethoxy-2,3-dihydro-1H-3-benzazepin-2-one; Ivabradine intermediate2; (Z)-3-(3-chloropropyl)-7; 3-(3-chloropropyl)-7,8-diMethoxy-2,3-dihydro-1H-3-benzazin-2-one; Ivabradine related compound 4; 3-(3-Chloropropyl)-7,8-dimetho; 3-(3-Chloro-propyl)-7,8-dimethoxy-1,3-dihydro-benzo[d]azin-2-one; 3-(3-Chloropropyl)-1,3-dihydro-7,8-diMethoxy-2H-3; 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-be; 3-(3-CHLOROPROPYL)-7,8-DIMETHOXY- 1,3-DIHYDRO-2H-3-BENZAZIN-2-ONE; 3-(3-chloropropyl)-7,8-dimethoxy-1H-3-benzazin-2-one; 2H-3-Benzazin-2-one, 3-(3-chloropropyl)-1,3-dihydro-7,8-diMethoxy; Ivabradine Impurity f; 7,8-Dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-3-benzazin-2-one; (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d]azepin-2(3H)-one; 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazin-2-one; 3-(3-Chloropropyl)-7,8-dimethoxy-2,3-dihydro-1H-benzoazin-2-one; 3-(3-Chloropropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one; 8-Demethyl Ivabradine Intermediate（Ivabradine Impurity 8）; 7,8-dimethoxy-3-(3-chloropropyl)-1,3-dihydro-2H-benzazepin-2-one; 3-(3-Chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazin-2-one (Ivabradine Impurity)

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 484.1±45.0 °C at 760 mmHg
• 分子式: C₁₅H₁₈ClNO₃
• 分子量: 295.761
• 闪点: 246.6±28.7 °C
• 精确质量: 295.097534
• PSA: 38.77000
• LogP: 3.28
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.545
• 储存条件: 室温，干燥

安全

• 海关编码: 2933990090

合成路线

73942-87-7 109-70-6 ~88% 85175-59-3

文献：US4490369 A1, ;

865-47-4 73942-87-7 109-70-6 ~% 85175-59-3

文献：US4584293 A1, ;

93-40-3 ~% 85175-59-3

文献：Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504

10313-60-7 ~% 85175-59-3

文献：Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504

73954-34-4 ~% 85175-59-3

文献：Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%