| 英文名 | AM-8553 |
|---|---|
| 英文别名 |
{(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxy-3-pentanyl]-3-methyl-2-oxo-3-piperidinyl}acetic acid
3-Piperidineacetic acid, 5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-3-methyl-2-oxo-, (3R,5R,6S)- AM-8553 {(3r,5r,6s)-5-(3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(2s,3s)-2-Hydroxypentan-3-Yl]-3-Methyl-2-Oxopiperidin-3-Yl}acetic Acid |
| 描述 | 一种有效的,选择性的,口服生物可利用的MDM2-p53相互作用抑制剂,HTRF IC50为1.1 nM,SJSA-1 EdU IC50为68 nM；表现出优异的药代动力学特性和体内功效。 |
|---|---|
| 参考文献 | References 1. Rew Y, et al. J Med Chem. 2012 Jun 14;55(11):4936-54. 2. Bernard D, et al. J Med Chem. 2012 Jun 14;55(11):4934-5. 3. Lucas BS, et al. J Am Chem Soc. 2012 Aug 1;134(30):12855-60. View Related Products by Target MDM2-p53 |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 沸点 | 644.0±55.0 °C at 760 mmHg |
| 分子式 | C25H29Cl2NO4 |
| 分子量 | 478.408 |
| 闪点 | 343.3±31.5 °C |
| 精确质量 | 477.147369 |
| LogP | 5.40 |
| 蒸汽压 | 0.0±2.0 mmHg at 25°C |
| 折射率 | 1.575 |
