109770-29-8

109770-29-8结构式

中文名	β-淀粉样蛋白1-28
英文名	BETA-AMYLOID (1-28)
英文别名	(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxy-propanoyl]amino]propanoyl]amino]-4-carboxy-butanoyl]amino]-3-phenyl-propanoyl]amino]-5-guanidino-pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-carboxy-propanoyl]amino]-3-hydroxy-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-carboxy-butanoyl]amino]-3-methyl-butanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-oxo-pentanoyl]amino]hexanoyl]amino]-4-methyl-pentanoyl]amino]-3-methyl-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-phenyl-propanoyl]amino]propanoyl]amino]-4-carboxy-butanoyl]amino]-3-carboxy-propanoyl]amino]-3-methyl-butanoyl]amino]acetyl]amino]-3-hydroxy-propanoyl]amino]-4-oxo-butanoyl]amino]hexanoic acid DAEFRHDSGYEVHHQKLVFFAEDVGSNK β-Amyloid (1-28)

描述	β-Amyloid (1-28) 是可参与金属结合的β-淀粉样蛋白片段。 β-淀粉样蛋白是在阿尔茨海默病患者的脑中形成淀粉样斑块的肽。
相关类别	信号通路 >> 神经信号通路 >> β淀粉样蛋白研究领域 >> 神经疾病多肽产品
靶点	Amyloid-β[1]
体内研究	β-淀粉样蛋白(1-28)片段被认为是有效的模型,用于检查关键组氨酸残基(His,His在小鼠和His,His,His在人类片段中)对Ab-Cu2 +相互作用的贡献[1]。铜在pH 7.4下与β-淀粉样蛋白(1-28)结合,具有Ka10 7 M-1的亲和力[2]。
参考文献	[1]. Kowalik-Jankowska T, et al. Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study. J Inorg Biochem. 2003 Jul 1;95(4):270-82. [2]. Syme CD, et al. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques. J Biol Chem. 2004 Apr 30;279(18):18169-77.