144485-81-4

• 常用中文名：7-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one
• 常用英文名：7-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one
• CAS号：144485-81-4
• 分子式：C₁₈H₁₂ClN₃O₂
• 分子量：337.76000
• 发布时间：2017-08-07 03:59:15
• 更新时间：2024-07-18 10:33:30

名称

• 英文名: 7-chloro-3-(3-methyl-1,2-oxazol-5-yl)-2-phenylquinazolin-4-one

物化性质

• 密度: 1.4g/cm3
• 沸点: 557.6ºC at 760mmHg
• 分子式: C₁₈H₁₂ClN₃O₂
• 分子量: 337.76000
• 闪点: 291ºC
• 精确质量: 337.06200
• PSA: 60.92000
• LogP: 4.00250
• 蒸汽压: 1.81E-12mmHg at 25°C
• 折射率: 1.69

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA2807010 CHEMICAL NAME : 4(3H)-Quinazolinone, 7-chloro-3-(3-methyl-5-isoxazolyl)-2-phenyl- CAS REGISTRY NUMBER : 144485-81-4 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H12-Cl-N3-O2 MOLECULAR WEIGHT : 337.78 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

合成路线

41995-04-4 ~% 144485-81-4

文献：Plescia; Diadone; Raffa; Bajardi; Caruso; Cutuli; Amico-Roxas Farmaco, 1992 , vol. 47, # 4 p. 465 - 475

144485-98-3 ~% 144485-81-4

文献：Plescia; Diadone; Raffa; Bajardi; Caruso; Cutuli; Amico-Roxas Farmaco, 1992 , vol. 47, # 4 p. 465 - 475

144485-94-9 1663-61-2 ~% 144485-81-4

文献：Farmaco, , vol. 47, # 4 p. 465 - 475

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