247068-82-2

• 常用中文名：卡非佐米中间体
• 常用英文名：[(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic acid 1,1-dimethylethyl ester
• CAS号：247068-82-2
• 分子式：C₁₄H₂₅NO₄
• 分子量：271.353
• 发布时间：2018-02-16 08:00:00
• 更新时间：2025-08-21 11:47:50

名称

• 中文名: 卡非佐米中间体
• 英文名: tert-butyl N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate
• 英文别名: Boc-leucine-epoxyketone; 2-Methyl-2-propanyl {(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}carbamate; Carbamic acid, N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-, 1,1-dimethylethyl ester; Boc-L-leucine epoxyketone

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 369.8±37.0 °C at 760 mmHg
• 分子式: C₁₄H₂₅NO₄
• 分子量: 271.353
• 闪点: 177.5±26.5 °C
• 精确质量: 271.178345
• PSA: 71.42000
• LogP: 2.87
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.472
• 储存条件: 2-8°C，干燥密封

合成路线

247068-81-1 ~25% 247068-82-2

文献：CREIGHTON UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MURRAY, Thomas F.; GERWICK, William H.; PEREIRA-BADILLA, Alban R.; KALE, Andrew; BYRUM, Tara; DEBONSI, Hosana; MOORE, Bradley S.; GILSON, Michael Kenneth; FENLEY, Andrew Patent: WO2013/9923 A1, 2013 ; Location in patent: Sheet 4; 5 ;

87694-50-6 ~% 247068-82-2

文献：CREIGHTON UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MURRAY, Thomas F.; GERWICK, William H.; PEREIRA-BADILLA, Alban R.; KALE, Andrew; BYRUM, Tara; DEBONSI, Hosana; MOORE, Bradley S.; GILSON, Michael Kenneth; FENLEY, Andrew Patent: WO2013/9923 A1, 2013 ;

13139-15-6 ~% 247068-82-2

文献：CENTRAX INTERNATIONAL, INC.; FAN, Xiaoqing, Michelle; CEN, Jian, James Patent: WO2014/18807 A1, 2014 ;

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