102043-42-5

• 常用中文名：(5α,8β)-3-Methoxy-17-methyl-6,7-didehydro-4,5-epoxymorphinan-8-ol hydrochloride (1:1)
• 常用英文名：(5α,8β)-3-Methoxy-17-methyl-6,7-didehydro-4,5-epoxymorphinan-8-ol hydrochloride (1:1)
• CAS号：102043-42-5
• 分子式：C₁₈H₂₂ClNO₃
• 分子量：335.82500
• 发布时间：2016-10-14 01:58:33
• 更新时间：2023-01-15 16:47:12

名称

• 英文名: (5α,8β)-3-Methoxy-17-methyl-6,7-didehydro-4,5-epoxymorphinan-8-ol hydrochloride (1:1)
• 英文别名: PGE2 1,15-lactone; (1R,2R,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptane-2,3-diol; (1R,2R,3S,4R)-2,6,6-trimethylcyclo[3.1.1]heptane-2,3-diol; (-)-podorhizol; (-)epi-podorhizol; (-)-pinane-2,3-diol; (-)-prostaglandin E2-1,15-lactone; Pinanediol [INCI]; (-)-2,3-Pinanediol; (1R,2R,3S,5R)-(-)-Pinanediol; (1R,2R,3S,5R)-(-)-2,3-Pinanediol; (-)-cis-Pinane-cis-2,3-diol; (3S,11aR,14R,14aR)-14-hydroxy-3-pentyl-6,7,8,11,11a,13,14,14a-octahydro-3H-cyclopenta[e]oxacyclotridecine-5,12-dione; (1R,2R,3S,5R)-2,6,6-trimethylbicyclo[3.3.1]heptane-2,3-diol; (-)-(1R,2R,3S,5R)-pinane-2,3-diol; (-)-pinanediol; (-)-pseudocodeine,hydrochloride; [1R-(1|A,2|A,3|A,5|A)]-2,6,6-Trimethylbicyclo[3.1.1]heptane-2,3-diol; (-)-Pseudocodein,Hydrochlorid; (-)-2-Hydroxyisopinocampheol

物化性质

• 沸点: 466ºC at 760mmHg
• 分子式: C₁₈H₂₂ClNO₃
• 分子量: 335.82500
• 闪点: 235.7ºC
• 精确质量: 335.12900
• PSA: 41.93000
• LogP: 2.24100
• 蒸汽压: 1.74E-09mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD1055000 CHEMICAL NAME : Morphinan-8-beta-ol, 6,7-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, hydrochloride CAS REGISTRY NUMBER : 102043-42-5 LAST UPDATED : 199009 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H21-N-O3.Cl-H MOLECULAR WEIGHT : 335.86 WISWESSER LINE NOTATION : T B6566 B6/CO 4ABBC R BX HO PN EU GHT&&TTJ DQ JO1 P1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 51,35,1934 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 579 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 66,182,1939

合成路线

467-08-3 ~25% 102043-42-5

文献：Journal of Organic Chemistry, , vol. 63, # 5 p. 1704 - 1705