68748-55-0

• 常用中文名：还原霉素
• 常用英文名：AM 6201
• CAS号：68748-55-0
• 分子式：C₁₄H₁₅NO₆
• 分子量：293.27200
• 发布时间：2016-04-28 21:43:13
• 更新时间：2024-01-10 16:30:51
• AM 6201, also known as Reductiomycin, is an alkaloid originally derived from Streptomyces xanthochromogenus that has been shown to exhibit antitumor activity against Ehrlich ascites carcinomas in mice.

名称

• 中文名: 还原霉素
• 英文名: 4-{(1E)-3-[(2-Hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-3-oxo-1-pro pen-1-yl}-2,3-dihydro-2-furanyl acetate
• 英文别名: tert-Butyl(phenyl)phosphine oxide; (+/-)-tert-butyl(phenyl)phosphane oxide; reductiomycin; Phosphine oxide,(1,1-dimethylethyl)phenyl; (t-butyl-phenyl) H phosphinate; (+/-)-P-t-butyl-P-phenylphosphane oxide; 2-3'-2''-acetoxy-2'',3'',-dihydrofur-4''-ylacrylamido-3-hydroxy-2-cyclopenten-1-one

物化性质

• 密度: 1.39g/cm3
• 沸点: 522.8ºC at 760 mmHg
• 分子式: C₁₄H₁₅NO₆
• 分子量: 293.27200
• 闪点: 270ºC
• 精确质量: 293.09000
• PSA: 105.42000
• LogP: 1.82500
• 折射率: 1.587

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UC6220000 CHEMICAL NAME : 2-Propenamide, 3-(5-(acetyloxy)-4,5-dihydro-3-furanyl)-N-(2-hydroxy- 5-oxo-1-cyclopenten-1- yl)-, (E)-(+)- CAS REGISTRY NUMBER : 68748-55-0 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C14-H15-N-O6 MOLECULAR WEIGHT : 293.30 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,649,1981

合成路线

4412-91-3 ~% 68748-55-0

文献：Ojika, Makoto; Niwa, Haruki; Shizuri, Yoshikazu; Yamada, Kiyoyuki Journal of the Chemical Society, Chemical Communications, 1982 , # 11 p. 628 - 629

83343-90-2 ~% 68748-55-0

文献：Ojika, Makoto; Niwa, Haruki; Shizuri, Yoshikazu; Yamada, Kiyoyuki Journal of the Chemical Society, Chemical Communications, 1982 , # 11 p. 628 - 629

83343-91-3 ~% 68748-55-0

文献：Ojika, Makoto; Niwa, Haruki; Shizuri, Yoshikazu; Yamada, Kiyoyuki Journal of the Chemical Society, Chemical Communications, 1982 , # 11 p. 628 - 629

83350-07-6 ~% 68748-55-0

文献：Ojika, Makoto; Niwa, Haruki; Shizuri, Yoshikazu; Yamada, Kiyoyuki Journal of the Chemical Society, Chemical Communications, 1982 , # 11 p. 628 - 629

83343-89-9 ~% 68748-55-0

文献：Ojika, Makoto; Niwa, Haruki; Shizuri, Yoshikazu; Yamada, Kiyoyuki Journal of the Chemical Society, Chemical Communications, 1982 , # 11 p. 628 - 629

83350-06-5 ~% 68748-55-0

文献：Ojika, Makoto; Niwa, Haruki; Shizuri, Yoshikazu; Yamada, Kiyoyuki Journal of the Chemical Society, Chemical Communications, 1982 , # 11 p. 628 - 629

83343-92-4 ~% 68748-55-0

文献：Ojika, Makoto; Niwa, Haruki; Shizuri, Yoshikazu; Yamada, Kiyoyuki Journal of the Chemical Society, Chemical Communications, 1982 , # 11 p. 628 - 629

上下游产品

上游产品  7
4412-91-3 83343-90-2 83343-91-3 83350-07-6
83343-89-9 83350-06-5 83343-92-4
下游产品  0