1881-37-4

• 常用中文名：Estra-1,3,5(10)-triene-3,17-diol,4-fluoro-, (17b)-(9CI)
• 常用英文名：Estra-1,3,5(10)-triene-3,17-diol,4-fluoro-, (17b)-(9CI)
• CAS号：1881-37-4
• 分子式：C₁₈H₂₃FO₂
• 分子量：290.37200
• 发布时间：2016-06-30 05:09:05
• 更新时间：2025-10-03 22:49:35

名称

• 英文名: (8R,9S,13S,14S)-4-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• 英文别名: N-triisopropylsilyl-4-fluoro-7-azaindole; 4-Fluoroestradiol; 1-triisopropyl-4-fluoro-7-azaindole

物化性质

• 密度: 1.225g/cm3
• 沸点: 427.1ºC at 760mmHg
• 分子式: C₁₈H₂₃FO₂
• 分子量: 290.37200
• 闪点: 212.1ºC
• 精确质量: 290.16800
• PSA: 40.46000
• LogP: 3.74830
• 蒸汽压: 4.7E-08mmHg at 25°C
• 折射率: 1.586

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG7535000 CHEMICAL NAME : Estra-1,3,5(10)-triene-3,17-beta-diol, 4-fluoro- CAS REGISTRY NUMBER : 1881-37-4 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C18-H23-F-O2 MOLECULAR WEIGHT : 290.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 360 mg/kg/15W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors REFERENCE : MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965- Volume(issue)/page/year: 23,278,1983

合成路线

50-28-2 ~20% 1881-37-4 16205-32-6

文献：Hebel, David; Kirk, Kenneth L. Journal of Fluorine Chemistry, 1990 , vol. 47, p. 179 - 183

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