41992-22-7

41992-22-7结构式
41992-22-7结构式

化源商城直购

中文名 锗螺胺
英文名 3-(8,8-diethyl-2-aza-8-germaspiro[4.5]decan-2-yl)-N,N-dimethylpropan-1-amine,dihydrochloride
英文别名 Spirogermanium hydrochloride
Spirogermanium dihydrochloride
2-Aza-8-germaspiro(4.5)decane-2-propanamine,8,8-diethyl-N,N-dimethyl-,dihydrochloride
Spiro-32
8,8-Diethyl-N,N-dimethyl-2-aza-8-germaspiro(4.5)decane-2-propanamine dihydrochloride
Spirogermanium hydrochloride (USAN)
沸点 382.8ºC at 760mmHg
分子式 C17H37ClGeN2
分子量 377.58200
闪点 165.8ºC
精确质量 378.18600
PSA 6.48000
LogP 4.65250

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL7618500
CHEMICAL NAME :
2-Aza-8-germaspiro(4.5)decane-2-propanamine, 8,8-diethyl-N,N-dimethyl, dihydrochloride
CAS REGISTRY NUMBER :
41992-22-7
LAST UPDATED :
198605
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C17-H36-Ge-N2.2Cl-H
MOLECULAR WEIGHT :
414.06
WISWESSER LINE NOTATION :
T6-GE- DXTJ A2 A2 D-& CT5N CXTJ A3N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
107 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB264-117
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
119 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Blood - hemorrhage Blood - other changes
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980