7021-46-7

• 常用中文名：5-AMINOTROPOLONE
• 常用英文名：5-AMINOTROPOLONE
• CAS号：7021-46-7
• 分子式：C₇H₇NO₂
• 分子量：137.13600
• 发布时间：2017-08-16 04:03:16
• 更新时间：2024-01-16 08:57:52

名称

• 英文名: 5-amino-2-hydroxycyclohepta-2,4,6-trien-1-one
• 英文别名: 2,4,6-CYCLOHEPTATRIEN-1-ONE,5-AMINO-2-HYDROXY; VII tropolone; 5-amino-2-hydroxytropone; 5-aminotopolone; 5-amino-tropolone; 5-Amino-2-hydroxy-2,4,6-cycloheptatrien-1-one; 5-Amino-tropolon

物化性质

• 密度: 1.356g/cm3
• 沸点: 262.3ºC at 760 mmHg
• 分子式: C₇H₇NO₂
• 分子量: 137.13600
• 闪点: 112.5ºC
• 精确质量: 137.04800
• PSA: 63.32000
• LogP: 0.91580
• 折射率: 1.638
• 储存条件: 库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GU3829500 CHEMICAL NAME : 2,4,6-Cycloheptatrien-1-one, 5-amino-2-hydroxy- CAS REGISTRY NUMBER : 7021-46-7 BEILSTEIN REFERENCE NO. : 1524779 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C7-H7-N-O2 MOLECULAR WEIGHT : 137.15 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 91,550,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 521 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 91,550,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 175 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 92,19,1972

合成路线

2297-94-1 ~94% 7021-46-7

文献：Research Foundation Itsuu Laboratory Patent: EP1357104 A1, 2003 ; Location in patent: Page/Page column 6-7 ;

533-75-5 ~% 7021-46-7

文献：Potenziano, James; Spitale, Robert; Janik, Mark E. Synthetic Communications, 2005 , vol. 35, # 15 p. 2005 - 2016

82968-90-9 ~0% 7021-46-7 22057-97-2

文献：Yamamoto, Hiroshi; Hara, Atsushi; Noguchi, Ayashi; Kawamoto, Heizan; Inokawa, Saburo; Nozoe, Tetsuo Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 5 p. 1594 - 1598

2297-94-1 7772-99-8 ~10% 7021-46-7

文献：Luminex Corporation Patent: US7867774 B2, 2011 ;

82968-89-6 ~% 7021-46-7 22057-97-2

文献：Yamamoto, Hiroshi; Hara, Atsushi; Noguchi, Ayashi; Kawamoto, Heizan; Inokawa, Saburo; Nozoe, Tetsuo Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 5 p. 1594 - 1598

82968-90-9 ~% 7021-46-7

文献：Yamamoto, Hiroshi; Hara, Atsushi; Noguchi, Ayashi; Kawamoto, Heizan; Inokawa, Saburo; Nozoe, Tetsuo Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 5 p. 1594 - 1598

33655-58-2 ~% 7021-46-7

文献：Kato,M. et al. Tetrahedron, 1971 , vol. 27, p. 4013 - 4020

21578-78-9 ~% 7021-46-7

文献：Sunagawa,G.; Watatani,M. Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, # 7 p. 1308 - 1315

67-56-1 52003-24-4 ~% 7021-46-7

文献：Nozoe et al. Sci. Rep. Tohoku Univ., Ser. 1: Phys., Chem., Astron., 1952 , vol. # 35, p. 1895,274,281

上下游产品

上游产品  7
2297-94-1 533-75-5 82968-90-9 7772-99-8
82968-89-6 33655-58-2 67-56-1
下游产品  2
3172-00-7 60423-21-4