898157-46-5

• 常用中文名：3-溴-1-噁-8-氮杂螺[4.5]癸烷-8-羧酸叔丁酯
• 常用英文名：1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester
• CAS号：898157-46-5
• 分子式：C₁₃H₂₂BrNO₃
• 分子量：320.223
• 发布时间：2018-12-22 08:04:43
• 更新时间：2024-04-05 11:05:02

名称

• 中文名: 3-溴-1-噁-8-氮杂螺[4.5]癸烷-8-羧酸叔丁酯
• 英文名: 1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester
• 英文别名: 2-Methyl-2-propanyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-bromo-, 1,1-dimethylethyl ester; tert-butyl (3R,5S)-6-amino-3,5-O-isopropylidene-3,5-dihydroxyhexanoate; (4R-Cis)-1,1-Dimethylethyl-6-Aminomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate; tert-Butyl-3-brom-1-oxa-8-azaspiro[4.5]decan-8-carboxylat; tert-butyl (3RS)-3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; Tert-butyl[(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 381.7±42.0 °C at 760 mmHg
• 分子式: C₁₃H₂₂BrNO₃
• 分子量: 320.223
• 闪点: 184.6±27.9 °C
• 精确质量: 319.078308
• PSA: 38.77000
• LogP: 1.82
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.532

合成路线

240401-09-6 ~42% 898157-46-5

文献：PFIZER INC.; LONG, Scott Allen; MEYERS, Marvin Jay; PELC, Matthew James; SCHWEITZER, Barbara Ann; THORARENSEN, Atli; WANG, Lijuan Jane Patent: WO2010/58318 A1, 2010 ; Location in patent: Page/Page column 26 ; WO 2010/058318 A1

954236-44-3 ~% 898157-46-5

文献：Meyers, Marvin J.; Long, Scott A.; Pelc, Matthew J.; Wang, Jane L.; Bowen, Scott J.; Schweitzer, Barbara A.; Wilcox, Mark V.; McDonald, Joseph; Smith, Sarah E.; Foltin, Susan; Rumsey, Jeanne; Yang, Young-Sun; Walker, Mark C.; Kamtekar, Satwik; Beidler, David; Thorarensen, Atli Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6545 - 6553

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