3573-50-0

3573-50-0结构式

英文名	2-deoxy-D-glucose 6-phosphate
英文别名	2-Deoxy-D-glucose-6-phosphate D-lyxo-2-Desoxy-hexose-6-phosphat 2-deoxyglucose-6-phosphate O6-phosphono-D-lyxo-2-deoxy-hexose [(2R,3S,4R)-2,3,4-trihydroxy-6-oxohexyl] dihydrogen phosphate D-lyxo-3,4,5-Trihydroxy-6-phosphonooxy-hexanal [(2R,3S,4R)-2,3,4-trihydroxy-6-keto-hexyl] dihydrogen phosphate O6-Phosphono-D-lyxo-2-desoxy-hexose

描述	2-脱氧-D-葡萄糖6-磷酸是2-脱氧-D-葡萄糖(2-DG)的中间体[1]。2-脱氧-D-葡萄糖被并入糖原[2]。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 代谢疾病
体外研究	作为D-葡萄糖模拟物,2-脱氧-D-葡萄糖(2-DG)由于2-脱氧-D-葡萄糖-6-磷酸(2-DG6P)的形成和细胞内积累而抑制糖酵解,抑制己糖激酶和葡萄糖-6-磷酸异构酶的功能,并诱导细胞死亡[3]。使用31P核磁共振波谱检测2-脱氧葡萄糖-6-磷酸(2-DG6P)的积累,用于评估离体灌注心脏胰岛素刺激前后的葡萄糖摄取[4]。
参考文献	[1]. Kuo SC, et al. Inhibition by 2-deoxy-D-glucose of synthesis of glycoprotein enzymes by protoplasts of Saccharomyces: relation to inhibition of sugar uptake and metabolism. J Bacteriol. 1972;111(2):419-429. [2]. Doenst T, et al. Complexities underlying the quantitative determination of myocardial glucose uptake with 2-deoxyglucose. J Mol Cell Cardiol. 1998;30(8):1595-1604. [3]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [4]. Paternostro G, et al. Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. Cardiovasc Res. 1995;30(2):205-211.