13977-28-1

• 常用中文名：盐酸恩布拉明
• 常用英文名：embramine hydrochloride
• CAS号：13977-28-1
• 分子式：C₁₈H₂₃BrClNO
• 分子量：384.73800
• 相关类别： 研究领域 其他
• 发布时间：2016-08-25 15:43:35
• 更新时间：2024-01-18 20:16:40
• Embramine (hydrochloride) 是用作抗组胺药和抗胆碱能活性分子的单乙醇胺。

名称

• 中文名: 盐酸恩布拉明
• 英文名: embramine hydrochloride
• 英文别名: Mebrophenhydramine hydrochloride; 2-[1-(4-Bromophenyl)-1-phenylethoxy]-N,N-dimethylethylamine hydrochloride; {2-[1-(4-bromo-phenyl)-1-phenyl-ethoxy]-ethyl}-dimethyl-amine,hydrochloride; {2-[1-(4-Brom-phenyl)-1-phenyl-aethoxy]-aethyl}-dimethyl-amin,Hydrochlorid; Bromadryl; EthanaMine,2-[1-(4-broMophenyl)-1-phenylethoxy]-N,N-diMethyl-,hydrochloride

物化性质

• 沸点: 405.8ºC at 760 mmHg
• 分子式: C₁₈H₂₃BrClNO
• 分子量: 384.73800
• 闪点: 199.2ºC
• 精确质量: 383.06500
• PSA: 12.47000
• LogP: 5.09280
• 蒸汽压: 8.55E-07mmHg at 25°C
• 储存条件: 库房通风低温干燥

生物活性

• 描述: Embramine (hydrochloride) 是用作抗组胺药和抗胆碱能活性分子的单乙醇胺。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. J M Varga, et al. Mechanism of allergic cross-reactions--I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody. Mol Immunol. 1991, 28, 6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KQ8400000 CHEMICAL NAME : Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N- dimethyl-, hydrochloride CAS REGISTRY NUMBER : 13977-28-1 LAST UPDATED : 199103 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H22-Br-N-O.Cl-H MOLECULAR WEIGHT : 384.78 WISWESSER LINE NOTATION : ER DX1&R&O2N1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 330 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,556,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,556,1989