179033-51-3

• 常用中文名：VX853
• 常用英文名：VX853
• CAS号：179033-51-3
• 分子式：C₄₃H₄₅ClN₄O₆
• 分子量：749.29400
• 发布时间：2017-03-04 01:38:14
• 更新时间：2024-01-09 17:34:43
• Timcodar, also known as VX-853, is a novel multidrug resistance Inhibitor. Timcodar was under clinical trials to treat cancaners and other diseases. Timcodar potentiated the activity of ethidium bromide (EtBr), a model efflux substrate, against three clinically significant gram-positive pathogens: Staphylococcus aureus, Enterococcus faecalis, and Streptococcus pneumoniae. Similar to reserpine, VX-853 directly blocked EtBr efflux in S. aureus. Furthermore, VX-853 was effective in lowering the MICs of several clinically used antibiotics, including fluoroquinolones, suggesting that VX-853 are representatives of a new class of bacterial efflux inhibitors with the potential for use in combination therapy.

名称

• 英文名: (2S)-N-benzyl-3-(4-chlorophenyl)-N-(1,5-dipyridin-4-ylpentan-3-yl)-2-[methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]amino]propanamide
• 英文别名: VX 853; UNII-U141W322WZ; Timcodar

物化性质

• 分子式: C₄₃H₄₅ClN₄O₆
• 分子量: 749.29400
• 精确质量: 748.30300
• PSA: 111.16000
• LogP: 7.07120