10423-37-7

• 常用中文名：西替酰胺
• 常用英文名：Citenamide
• CAS号：10423-37-7
• 分子式：C₁₆H₁₃NO
• 分子量：235.28100
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-09-06 15:45:21
• 更新时间：2024-01-06 19:25:48
• Citenamide 是一种抗惊厥药，具有镇静、催眠效果。

名称

• 中文名: 西替酰胺
• 英文名: 11H-dibenzo[1,2-a:1',2'-e][7]annulene-11-carboxamide
• 英文别名: Citenamide; Dibenzo<a,e>cycloheptatrien-5-carboxamid; 5H-Dibenzo<a.d>cyclohepten-5-carbonsaeureamid; Dibenzo<a,e>1,3,5-cycloheptatrien-5-carboxamid; Cytenamide; AY-15,613; percentH-Dibenzo<a,b>cyclohepten-5-carboxamid

物化性质

• 密度: 1.203g/cm3
• 沸点: 487.1ºC at 760 mmHg
• 分子式: C₁₆H₁₃NO
• 分子量: 235.28100
• 闪点: 248.4ºC
• 精确质量: 235.10000
• PSA: 43.09000
• LogP: 3.48790
• 蒸汽压: 1.23E-09mmHg at 25°C
• 折射率: 1.643
• 储存条件: 2-8℃

生物活性

• 描述: Citenamide 是一种抗惊厥药,具有镇静、催眠效果。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: Citenamide(Cytenamide,CYT)是Carbamazepine(CBZ)的类似物,Carzamazepine是一种用于控制癫痫发作的二苯并氮杂类药物。
• 参考文献:

  [1]. Johnston A, et al. Cytenamide-formic acid (1/1). Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 5;64(Pt 8):o1379-80.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HO7700000 CHEMICAL NAME : 5H-Dibenzo(a,d)cycloheptene-5-carboxamide CAS REGISTRY NUMBER : 10423-37-7 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C16-H13-N-O MOLECULAR WEIGHT : 235.30 WISWESSER LINE NOTATION : L C676 BHJ BVZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 582 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 440 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,91,1972

安全

• 海关编码: 2924299090

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%