11051-88-0

• 常用中文名：儿茶酚醇
• 常用英文名：Cochliodinol
• CAS号：11051-88-0
• 分子式：C₃₂H₃₀N₂O₄
• 分子量：506.59
• 相关类别： 研究领域 代谢疾病
• 发布时间：2017-11-11 19:52:34
• 更新时间：2024-01-11 14:10:43
• Cochliodinol (compound 1) 是来源于 Apis mellifera ligustica 的代谢产物。Cochliodinol 具有较强的 2,2-二苯基-1苦基肼 (DPPH) 自由基清除活性 (IC50=3.06 μg/mL)。

名称

• 中文名: 儿茶酚醇
• 英文名: 2,5-dihydroxy-3,6-bis[5-(3-methylbut-2-enyl)-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione
• 英文别名: 2,5-dihydroxy-3,6-bis-[5-(3-methyl-but-2-enyl)-indol-3-yl]-[1,4]benzoquinone; Cochliodinol; 3,6-Bis(5-(3-methyl-2-butenyl)indol-3-yl)-2,5-dihydroxy-p-benzoquinone; p-Benzoquinone,3,6-bis(5-(3-methyl-2-butenyl)indol-3-yl)-2,5-dihydroxy; chochliodinol; 2,5-Cyclohexadiene-1,4-dione,2,5-dihydroxy-3,6-bis(5-(3-methyl-2-butenyl)-1H-indol-3-yl); 2,5-Dihydroxy-3,6-bis(5-(3-methyl-2-butenyl)-1H-indol-3-yl)-2,5-cyclohexadiene-1,4-dione

物化性质

• 密度: 1.344g/cm3
• 沸点: 790ºC at 760mmHg
• 分子式: C₃₂H₃₀N₂O₄
• 分子量: 506.59
• 闪点: 431.6ºC
• 精确质量: 506.22100
• PSA: 106.18000
• LogP: 7.05680
• 蒸汽压: 2.66E-26mmHg at 25°C
• 折射率: 1.73

生物活性

• 描述: Cochliodinol (compound 1) 是来源于 Apis mellifera ligustica 的代谢产物。Cochliodinol 具有较强的 2,2-二苯基-1苦基肼 (DPPH) 自由基清除活性 (IC50=3.06 μg/mL)。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Cui P, et al. Community composition, bacterial symbionts, antibacterial and antioxidant activities of honeybee-associated fungi. BMC Microbiol. 2022 Jun 27;22(1):168.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DK3529000 CHEMICAL NAME : p-Benzoquinone, 3,6-bis(5-(3-methyl-2-butenyl)indol-3-yl)-2,5-dihydro xy- CAS REGISTRY NUMBER : 11051-88-0 BEILSTEIN REFERENCE NO. : 5188623 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C32-H30-N2-O4 MOLECULAR WEIGHT : 506.64 WISWESSER LINE NOTATION : T56 BMJ G1U1Y1&1 D- BL6V DVJ CQ FQ E- DT56 BMJ G1U1Y1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 221 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,310,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,310,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 147 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,310,1980

合成路线

56489-25-9 ~% 11051-88-0

文献：Horcher; Schwenner; Franck 1986 , vol. 1986, # 10 p. 1765 - 1771

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