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N-(对甲酰基肉桂酰)邻氨基苯甲酸

N-(对甲酰基肉桂酰)邻氨基苯甲酸用途

氨基苯甲酸 (ACA) 是一种广谱磷脂酶 A2 抑制剂，可阻断瞬时受体电位 (TRP) 通道。抑制心室肌细胞中钙激活的氯化物电流。ACA 调节多种离子通道。

N-(对甲酰基肉桂酰)邻氨基苯甲酸名称

[ CAS 号 ]:
99196-74-4

[ 中文名 ]:
N-(对甲酰基肉桂酰)邻氨基苯甲酸

[ 英文名 ]:
N-(P-Amylcinnamoyl)Anthranilic Acid

[英文别名 ]:

BML 264
N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID

N-(对甲酰基肉桂酰)邻氨基苯甲酸物理化学性质

[ 密度 ]:
1.178±0.06 g/cm3 (20 °C, 760 mmHg)

[ 沸点 ]:
563.1±50.0 °C (760 mmHg)

[ 分子式 ]:
C₂₁H₂₃NO₃

[ 分子量 ]:
337.41200

[ 精确质量 ]:
337.16800

[ PSA ]:
66.40000

[ LogP ]:
4.84240

[ 外观性状 ]:
固体

[ 储存条件 ]:
室温

N-(对甲酰基肉桂酰)邻氨基苯甲酸安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
N

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

N-(对甲酰基肉桂酰)邻氨基苯甲酸文献

Des-Arg9-bradykinin causes kinin B1 receptor mediated endothelium-independent contractions in endotoxin-treated porcine coronary arteries.

Pharmacol. Res. 90 , 18-24, (2014)

This study examined responses of isolated pig coronary arteries after kinin B1 receptor induction by endotoxin. Des-Arg9-bradykinin (DBK) induced concentration-dependent, endothelium-independent contr...

Enhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel.

Oncol. Rep. 34 , 1589-98, (2015)

We previously demonstrated a unique protective role for the transient receptor potential, melastatin-2 (TRPM2) cation channel in breast cancer cells. In the present study, we investigated the chemothe...

Diglycolic acid is the nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells in vitro.

Toxicol. Sci. 124 , 35-44, (2011)

Diethylene glycol (DEG), a solvent and chemical intermediate, can produce an acute toxic syndrome, the hallmark of which is acute renal failure due to cortical tubular degeneration and proximal tubula...

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