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2-氨基-4-硝基苯甲醚

2-氨基-4-硝基苯甲醚用途

作为染料、颜料及有机合成中间体

2-氨基-4-硝基苯甲醚名称

[ CAS 号 ]:
99-59-2

[ 中文名 ]:
2-氨基-4-硝基苯甲醚

[ 英文名 ]:
2-Amino-4-Nitroanisole

[中文别名 ]:

[英文别名 ]:

2-Amino-4-nitro anisidine
5-Nitro-2-methoxyaniline
2-Amino-4-Nitroanisole
Benzenamine, 2-methoxy-5-nitro-
2-Methoxy-5-nitrobenzenamine
3-Amino-4-methoxynitrobenzene
MFCD00007261
2-Methoxy-5-nitroaniline
5-Nitro-2-anisidine
EINECS 202-770-5

2-氨基-4-硝基苯甲醚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
351.8±22.0 °C at 760 mmHg

[ 熔点 ]:
117-119 °C(lit.)

[ 分子式 ]:
C₇H₈N₂O₃

[ 分子量 ]:
168.150

[ 闪点 ]:
166.6±22.3 °C

[ 精确质量 ]:
168.053497

[ PSA ]:
81.07000

[ LogP ]:
1.69

[ 外观性状 ]:
橙色至棕色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
Slightly soluble.

2-氨基-4-硝基苯甲醚MSDS

2-氨基-4-硝基苯甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ7175000

CHEMICAL NAME :: o-Anisidine, 5-nitro-

CAS REGISTRY NUMBER :: 99-59-2

BEILSTEIN REFERENCE NO. :: 0879620

LAST UPDATED :: 199710

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C7-H8-N2-O3

MOLECULAR WEIGHT :: 168.17

WISWESSER LINE NOTATION :: WNR CZ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 mg/kg/30D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Liver - changes in liver weight Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 109 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 413 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 524 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 218 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4368 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3444 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2184 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4368 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 umol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,11,1978 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,133,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,133,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

2-氨基-4-硝基苯甲醚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S26-S36-S45-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
BZ7175000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2922299090

2-氨基-4-硝基苯甲醚合成路线

2-氨基-4-硝基苯甲醚上下游产品

2-氨基-4-硝基苯甲醚上游产品

2-氨基-4-硝基苯甲醚下游产品

2-氨基-4-硝基苯甲醚制备

由2,4-二硝基氯苯经甲氧基化、还原而得。1.甲氧基化将熔融的2,4-二硝基氯苯加入反应锅，再加入甲醇。加热至40℃左右，在4h内先快后慢地加入30%氢氧化钠溶液，温度控制在58-60℃。反应至酚酞试纸对料液显橘红色时为终点，得2,4-二硝基苯甲醚，收率为95%。2.还原将上述甲氧基化生成物冷至30℃，在4h内先快后慢地加入18%的二硫化钠溶液，反应温度从30℃逐度上升至50℃。加完后在50-55℃保温半小时。反应完成后冷却至20℃，压滤、洗涤、干燥，得2-甲氧基-5-硝基苯胺。收率为76%。

2-氨基-4-硝基苯甲醚海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-氨基-4-硝基苯甲醚文献

Removal of multi-substituted nitroaromatic pollutants by zero valent iron: a comparison of performance, kinetics, toxicity and mechanisms.

Phys. Chem. Chem. Phys. 17 , 22072-8, (2015)

Reductive degradation of three typical multi-substituted nitroaromatic pollutants by zero valent iron was comprehensively compared in terms of performance, kinetics, toxicity and mechanisms in this st...

Microbial toxicity of the insensitive munitions compound, 2,4-dinitroanisole (DNAN), and its aromatic amine metabolites.

J. Hazard. Mater. 262 , 281-7, (2013)

2,4-Dinitroanisole (DNAN) is an insensitive munitions compound considered to replace conventional explosives such as 2,4,6-trinitrotoluene (TNT). DNAN undergoes facile microbial reduction to 2-methoxy...

Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives.

Bioorg. Med. Chem. 13(23) , 6513-20, (2005)

A series of 5-(9-acridinylamino)anisidines were synthesized by condensing methoxy-substituted 1,3-phenylenediamines (10 and 11) with 9-chloroacridine derivatives to form 5-(9-acridinylamino)-m-anisidi...

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