苯磺酰氯
苯磺酰氯用途
用途二:用于制磺胺药物等,也用于鉴定各种胺
用途三:苯磺酰氯是一种有机合成原料,在农药上用于合成沙蚕毒类杀虫剂杀虫磺的中间体硫代苯磺酸钠,另外也是医药和染料的中间体。
苯磺酰氯名称
[ CAS 号 ]:
98-09-9
[ 中文名 ]:
苯磺酰氯
[ 英文名 ]:
chlorophenylsulfone
[中文别名 ]:
[英文别名 ]:
- Benzene sulfonyl chloride
- MFCD00007426
- chlorophenylsulfone
- EINECS 202-636-6
- Benzenesulfonic chloride
- Benzenesulfochloride
- Benzenesulfonyl chloride
- Phenylsulfonyl chloride
- Benzenesulphonyl chloride
- Benzenesulfonic acid chloride
苯磺酰氯物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
251.5±9.0 °C at 760 mmHg
[ 熔点 ]:
14.5 °C
[ 分子式 ]:
C6H5ClO2S
[ 分子量 ]:
176.621
[ 闪点 ]:
105.9±18.7 °C
[ 精确质量 ]:
175.969879
[ PSA ]:
42.52000
[ LogP ]:
1.99
[ 外观性状 ]:
透明液体
[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C
[ 折射率 ]:
1.554
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、H发孔剂、碱类、氰化物分开存放
[ 稳定性 ]:
Stable. Incompatible with water, strong oxidizing agents, strong bases, methyl formamide, dimethyl sulfoxide.
[ 水溶解性 ]:
may decompose
苯磺酰氯MSDS
苯磺酰氯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DB8750000
- CHEMICAL NAME :
- Benzenesulfonyl chloride
- CAS REGISTRY NUMBER :
- 98-09-9
- BEILSTEIN REFERENCE NO. :
- 0606926
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C6-H5-Cl-O2-S
- MOLECULAR WEIGHT :
- 176.62
- WISWESSER LINE NOTATION :
- WSGR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1960 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 20,513,1969
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1870 mg/m3/1H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS0510391
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 76 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 20,513,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 828 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(6),19,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 828 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(6),19,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 828 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(6),19,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1145 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)
苯磺酰氯安全信息
[ 符号 ]:
GHS05, GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302 + H332-H314-H317-H334
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
C:Corrosive
[ 风险声明 (欧洲) ]:
R22;R29;R34
[ 安全声明 (欧洲) ]:
S23-S26-S36/37/39-S45
[ 危险品运输编码 ]:
UN 2225 8/PG 3
[ WGK德国 ]:
1
[ RTECS号 ]:
DB8750000
[ 包装等级 ]:
III
[ 危险类别 ]:
8
[ 海关编码 ]:
2904909090
苯磺酰氯合成路线
苯磺酰氯上下游产品
苯磺酰氯上游产品
苯磺酰氯下游产品
苯磺酰氯制备
其制备方法是将苯和氯磺酸以1∶3(mol)在20~30℃反应2h,即得到苯磺酰氯粗品,经精制得到成品。
苯磺酰氯海关
[ 海关编码 ]: 2904909090
[ 中文概述 ]:
2904909090 其他烃的磺化、硝化、亚硝化衍生物(不论是否卤化). 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
苯磺酰氯文献
J. Enzyme Inhib. Med. Chem. 29(6) , 846-67, (2014)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatme...
Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents.Eur. J. Med. Chem. 90 , 428-35, (2015)
Hepatitis B virus (HBV) is a causative reagent that frequently causes progressive liver diseases, leading to the development of acute, chronic hepatitis, cirrhosis, and eventually hepatocellular carci...
Comparison of manual and benzenesulfonyl chloride-semiautomated thiochrome methods for determination of thiamine in foods.J. Assoc. Off. Anal. Chem. 64(3) , 616-22, (1981)
A semiautomated procedure was used to measure the fluorescence of sample extracts before and after the addition of benzenesulfonyl chloride (BSC). Addition of BSC inhibited thiochrome formation and pr...
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¥108.0/500g
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产品详情:苯磺酰氯
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¥94.0/500g
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相关化合物
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