乙二醇二甲基丙烯酸酯

乙二醇二甲基丙烯酸酯用途

Ethylene glycol dimethacrylate 是一种甲基丙烯酸酯单体,对人牙龈成纤维细胞 (HGF) 具有细胞毒性和基因毒性作用。Ethylene glycol dimethacrylate 会增加细胞内活性氧 (ROS) 的产生,导致 DNA 损伤,增加细胞凋亡 (apoptosis) 并导致细胞周期停滞在 G1/G0 期。

乙二醇二甲基丙烯酸酯名称

[ CAS 号 ]:
97-90-5

[ 中文名 ]:
乙二醇二甲基丙烯酸酯

[ 英文名 ]:
Ethylene methacrylate

[中文别名 ]:

[英文别名 ]:

Ethylene methacrylate
Ethylene dimethacrylate
Glycol dimethacrylate
Ethane-1,2-diyl bis(2-methylprop-2-enoate)
1UY1&VO2OVY1&U1
MFCD00008590
2-Propenoic acid, 2-methyl-, 1,2-ethanediyl ester
Ethyldiol methacrylate
Ethane-1,2-diyl bis(2-methylacrylate)
EINECS 202-617-2

乙二醇二甲基丙烯酸酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 其他

[参考文献]

[1]. Anna Bielecka-Kowalska, et al. Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species. Toxicol In Vitro. 2018 Mar:47:8-17.

乙二醇二甲基丙烯酸酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
260.6±13.0 °C at 760 mmHg

[ 熔点 ]:
-40 °C

[ 分子式 ]:
C₁₀H₁₄O₄

[ 分子量 ]:
198.216

[ 闪点 ]:
121.8±18.2 °C

[ 精确质量 ]:
198.089203

[ PSA ]:
52.60000

[ LogP ]:
2.78

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
>1 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.449

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Unstable - may polymerize upon exposure to light. Incompatible with strong acids, strong oxidizing agents, strong bases.

[ 水溶解性 ]:
soluble

乙二醇二甲基丙烯酸酯MSDS

乙二醇二甲基丙烯酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OZ4400000

CHEMICAL NAME :: Methacrylic acid, ethylene ester

CAS REGISTRY NUMBER :: 97-90-5

BEILSTEIN REFERENCE NO. :: 1776663

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H14-O4

MOLECULAR WEIGHT :: 198.24

WISWESSER LINE NOTATION :: 1UY1&VO2OVY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 5820 umol/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 17,264,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3204 No. of Facilities: 983 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 6295 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3204 No. of Facilities: 562 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 9073 (estimated) No. of Female Employees: 3604 (estimated)

乙二醇二甲基丙烯酸酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H335

[ 警示性声明 ]:
P280-P304 + P340 + P312-P333 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R37;R43

[ 安全声明 (欧洲) ]:
S24-S37

[ 危险品运输编码 ]:
UN3334 9

[ WGK德国 ]:
1

[ RTECS号 ]:
OZ4400000

[ 危险类别 ]:
9.0

[ 海关编码 ]:
2916140000

乙二醇二甲基丙烯酸酯合成路线

乙二醇二甲基丙烯酸酯上下游产品

乙二醇二甲基丙烯酸酯上游产品

乙二醇二甲基丙烯酸酯下游产品

乙二醇二甲基丙烯酸酯制备

由乙二醇与甲基丙烯酸在硫酸催化下直接酯化，所得粗品经减压精馏后成品。工艺流程：在装有电动搅拌器、温度计、空气导管、分水器和回流冷凝管的四口瓶中，加入0.345mol的甲基丙烯酸和0.15mol乙二醇，3g催化剂对甲苯磺酸，0.08g对苯二酚和适量的溶剂，并通过续加溶剂控制反应温度低于85℃以下，通入空气量为2ml/min,不断搅拌回流7h。冷却后加入10ml水，搅拌10min，物料转移至分液漏斗中，分出水层，有机层依次用10%NaOH溶液和不洗至中性，分出水层。在对甲氧基苯酚阻聚下减压蒸出低沸点的溶剂，称重，计算收率约为93.3%。

乙二醇二甲基丙烯酸酯海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

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