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2,3-二溴-1-丙醇

2,3-二溴-1-丙醇用途

【用途一】
用于有机合成，作溶剂和阻燃剂。作解毒药二巯基丙醇以及聚氨酯泡沫塑料、不饱和聚酯、酚醛、环氧树脂及聚丙烯类阻燃产品的中间体。

2,3-二溴-1-丙醇名称

[ CAS 号 ]:
96-13-9

[ 中文名 ]:
2,3-二溴-1-丙醇

[ 英文名 ]:
2,3-Dibromo-1-propanol

[中文别名 ]:

[英文别名 ]:

2,3-dibromopropan-1-ol
MFCD00004699
EINECS 202-480-9

2,3-二溴-1-丙醇物理化学性质

[ 密度 ]:
2.12 g/mL at 25 °C(lit.)

[ 沸点 ]:
95-97 °C10 mm Hg(lit.)

[ 熔点 ]:
8ºC

[ 分子式 ]:
C₃H₆Br₂O

[ 分子量 ]:
217.88700

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
215.87900

[ PSA ]:
20.23000

[ LogP ]:
1.13710

[ 外观性状 ]:
透明无色至略黄色粘性液体

[ 折射率 ]:
n20/D 1.559(lit.)

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
5-10 g/100 mL at 20 ºC

2,3-二溴-1-丙醇MSDS

2,3-二溴-1-丙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB0175000

CHEMICAL NAME :: 1-Propanol, 2,3-dibromo-

CAS REGISTRY NUMBER :: 96-13-9

BEILSTEIN REFERENCE NO. :: 1719127

LAST UPDATED :: 199806

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C3-H6-Br2-O

MOLECULAR WEIGHT :: 217.91

WISWESSER LINE NOTATION :: Q1YE1E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 681 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9920 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/m3/4H-3W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11505 mg/kg/13W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 47940 mg/kg/51W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 37170 mg/kg/42W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Heritable translocation test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,213,1983

2,3-二溴-1-丙醇安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H332-H311-H350-H361-H412

[ 警示性声明 ]:
P201-P273-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R20/22;R24;R45;R52/53;R62

[ 安全声明 (欧洲) ]:
S53-S45-S61

[ 危险品运输编码 ]:
UN 2810 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UB0175000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2905590090

2,3-二溴-1-丙醇合成路线

2,3-二溴-1-丙醇上下游产品

2,3-二溴-1-丙醇上游产品

2,3-二溴-1-丙醇下游产品

2,3-二溴-1-丙醇制备

1.由丙烯醇与溴加成而得。将丙烯醇加入四氯化碳溶剂中，在25-27℃加溴时行溴化，加毕保温1h（在50±2℃），然后蒸馏回收四氯化碳，用水和碳酸钠洗至pH值为7-8，干燥，过滤清亮，减压蒸馏，收集140-160℃（2.66kPa）馏分即为成品。也可以不用溶剂进行生产：将丙烯醇加入反应锅内，搅拌冷却。在10℃以下滴加溴素。滴加速度以反应温度不超过20℃为宜。加毕，在室温下搅拌1.5h，加水搅拌10min，静置分取油层，加碳酸钠液中和至中性。静置，分取油层，减压蒸馏，收集115-125℃（3.99-5.32kPa）馏分，得2,3-二溴-1-丙醇。

2.制法：

于装有搅拌器、温度计、滴液漏斗的反应瓶中，加入丙烯醇(2)58g（1.0mol），四氯化碳100mL，水浴冷却下，慢慢滴加溴素160g(1.0mol),控制滴加速度，以保持反应液温度在25～27℃.加完后慢慢升温至50℃，并保温反应1h。减压蒸出四氯化碳，剩余物依次用水、碳酸钠溶液洗涤至中性。无水硫酸钠干燥，减压蒸馏，收集115～125℃/4～5.2kPa的馏分，得2,3-1-丙醇(1)175g,收率80%。

2,3-二溴-1-丙醇海关

[ 海关编码 ]: 2905590090

[ 中文概述 ]:
2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2,3-二溴-1-丙醇文献

2-Haloacrylic acids as indicators of mutagenic 2-haloacrolein intermediates in mammalian metabolism of selected promutagens and carcinogens.

J. Agric. Food Chem. 30(4) , 627-31, (1982)

A combination of in vivo selection and cell sorting for the identification of enantioselective biocatalysts.

Angew. Chem. Int. Ed. Engl. 50(37) , 8584-7, (2011)

J. Heterocycl. Chem. 28 , 891, (1991)

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