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2-氨基-4-氯苯酚

2-氨基-4-氯苯酚用途

【用途一】
用于制备酸性媒介RH、酸性络合紫5RN及活性染料，也可用于制备原料药氯唑沙宗
【用途二】
氯唑沙宗的中间体。

2-氨基-4-氯苯酚名称

[ CAS 号 ]:
95-85-2

[ 中文名 ]:
2-氨基-4-氯苯酚

[ 英文名 ]:
2-Amino-4-chlorophenol

[中文别名 ]:

[英文别名 ]:

EINECS 202-458-9
2-Amino-4-chlorophenol
5-Chloro-2-hydroxyaniline
Phenol, 2-amino-4-chloro-
MFCD00007694

2-氨基-4-氯苯酚物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
276.8±25.0 °C at 760 mmHg

[ 熔点 ]:
136-141 °C(lit.)

[ 分子式 ]:
C₆H₆ClNO

[ 分子量 ]:
143.571

[ 闪点 ]:
121.2±23.2 °C

[ 精确质量 ]:
143.013794

[ PSA ]:
46.25000

[ LogP ]:
1.67

[ 外观性状 ]:
棕色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.651

[ 储存条件 ]:
库房通风低温干燥,与食品添加剂、氧化剂分开存放

[ 水溶解性 ]:
Insoluble.

2-氨基-4-氯苯酚MSDS

2-氨基-4-氯苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ5700000

CHEMICAL NAME :: Phenol, 2-amino-4-chloro-

CAS REGISTRY NUMBER :: 95-85-2

BEILSTEIN REFERENCE NO. :: 0774859

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H6-Cl-N-O

MOLECULAR WEIGHT :: 143.58

WISWESSER LINE NOTATION :: ZR BQ EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1030 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 333 ug/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82099 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 168 (estimated)

2-氨基-4-氯苯酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37/39

[ 危险品运输编码 ]:
UN 2673 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
SJ5700000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29222900

2-氨基-4-氯苯酚合成路线

2-氨基-4-氯苯酚上下游产品

2-氨基-4-氯苯酚上游产品

2-氨基-4-氯苯酚下游产品

2-氨基-4-氯苯酚制备

1、2-硝基对氯苯酚硫化钠还原法由对氯苯酚经硝化、还原而得。

2、2-硝基对氯苯酚加氢还原法 2-硝基对氯苯酚300g在水溶性悬浮液中，在氢压4.05Mpa和60℃，PH=7（60℃）条件下，用镍催化剂还原。氢用量145L，pH用磷酸二氢钠水合物50g和氢氧化钠（33%）水溶液257.5g调节。反应毕，放压，用氮气洗涤并用氮气压入受器，在此加热至95℃，用氢氧化钠调pH=10.7（95℃），加入活性炭和硅藻土，激烈搅拌，过滤。滤液用浓盐酸调pH=5.2（20℃），冷却至0℃，过滤，干燥。然后用亚硫酸氢钠4.5g处理，过滤，干燥，这样操作重复四次，然后于2.67kpa下蒸馏，收集80℃左右馏分，干燥，得产品，收率97.7%。

2-氨基-4-氯苯酚海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-氨基-4-氯苯酚文献

Metabolism of 4-chloro-2-nitrophenol in a gram-positive bacterium, Exiguobacterium sp. PMA.

Microb. Cell Fact. 11 , 150, (2012)

Chloronitrophenols (CNPs) are widely used in the synthesis of dyes, drugs and pesticides, and constitute a major group of environmental pollutants. 4-Chloro-2-nitrophenol (4C2NP) is an isomer of CNPs ...

A new way for synthesis of phenoxazine and diphenoxazine derivatives via electrochemical method.

Chem. Pharm. Bull. 59(10) , 1209-13, (2011)

Electrochemical oxidation of hydroquinone (1a) and 2,3-dimethylhydroquinone (1b) have been studied in the presence of 2-aminophenol (3a) and 2-amino-4-chlorophenol (3b), as nucleophiles in phosphate b...

Stability-indicating TLC-densitometric method for simultaneous determination of paracetamol and chlorzoxazone and their toxic impurities.

J. Chromatogr. Sci. 51(2) , 187-91, (2013)

A highly sensitive, selective and accurate thin-layer chromatographic (TLC)-densitometric method has been developed and validated for the simultaneous determination of paracetamol (PAR) and chlorzoxaz...

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