非那吡啶

非那吡啶用途

非那吡啶对泌尿道有局部镇痛作用,通常用于缓解由泌尿道感染、手术或泌尿道损伤引起的疼痛、刺激、不适或紧迫感[1]。

非那吡啶名称

[ CAS 号 ]:
94-78-0

[ 中文名 ]:
非那吡啶

[ 英文名 ]:
3-(Phenylazo)-2,6-pyridinediamine

[中文别名 ]:

3-苯氮杂-2,6-二氨基吡啶

[英文别名 ]:

Baridium
Pyridium
3-Phenylazo-pyridin-2,6-diyldiamin
Viridium
2,6-diamino-3-(phenylazo)pyridine
Sedural
Pyridiate
Gastracid
Urodine
3-phenylazo-pyridine-2,6-diamine

非那吡啶生物活性

[ 描述 ]:

非那吡啶对泌尿道有局部镇痛作用,通常用于缓解由泌尿道感染、手术或泌尿道损伤引起的疼痛、刺激、不适或紧迫感[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Norris RD, et al. A prospective, randomized, double-blinded placebo-controlled comparison of extended release oxybutynin versus phenazopyridine for the management of postoperative ureteral stent discomfort. Urology. 2008 May;71(5):792-5.

非那吡啶物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
442.3ºC at 760mmHg

[ 熔点 ]:
235 - 240ºC

[ 分子式 ]:
C₁₁H₁₁N₅

[ 分子量 ]:
213.23900

[ 精确质量 ]:
213.10100

[ PSA ]:
89.65000

[ LogP ]:
3.82380

[ 外观性状 ]:
暗红色至紫罗兰色结晶粉末

[ 折射率 ]:
1.6880 (estimate)

[ 储存条件 ]:
20°C，惰性气体

非那吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7700000

CHEMICAL NAME :: Pyridine, 2,6-diamino-3-(phenylazo)-

CAS REGISTRY NUMBER :: 94-78-0

BEILSTEIN REFERENCE NO. :: 0184497

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H11-N5

MOLECULAR WEIGHT :: 213.27

WISWESSER LINE NOTATION :: T6NJ BZ CNUNR& FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 51,200,1934

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 35,423,1960 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 11,212,1957 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,117,1975 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,117,1975 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

非那吡啶安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933399090

非那吡啶合成路线

详细合成路线

非那吡啶上下游产品

非那吡啶上游产品

非那吡啶下游产品

非那吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%