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1,3-二氯-2-丁烯

1,3-二氯-2-丁烯用途

1.用于有机合成

2.用于雌甾和19失碳甾体全合成中构建A一环和其它一些扩还反应

1,3-二氯-2-丁烯名称

[ CAS 号 ]:
926-57-8

[ 中文名 ]:
1,3-二氯-2-丁烯

[ 英文名 ]:
1,3-dichloro-2-butene

[中文别名 ]:

1，3-二氯-2-丁烯

[英文别名 ]:

MFCD00000861
EINECS 213-138-3
1,3-dichloro-2-butene

1,3-二氯-2-丁烯物理化学性质

[ 密度 ]:
1.16

[ 沸点 ]:
125-129 °C

[ 分子式 ]:
C₄H₆Cl₂

[ 分子量 ]:
124.99600

[ 闪点 ]:
33 °C

[ 精确质量 ]:
123.98500

[ LogP ]:
2.36780

[ 外观性状 ]:
液体;Colorless to Light yellow clear liquid

[ 折射率 ]:
1.469-1.473

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
水溶性：不溶；混溶：丙酮,乙醚,苯,乙醇

1,3-二氯-2-丁烯MSDS

1,3-二氯-2-丁烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM4760000

CHEMICAL NAME :: 2-Butene, 1,3-dichloro-

CAS REGISTRY NUMBER :: 926-57-8

LAST UPDATED :: 199801

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H6-Cl2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3930 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962- Volume(issue)/page/year: 9(6),66,1969

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4400 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962- Volume(issue)/page/year: 9(6),66,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/m3/4H/5W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962- Volume(issue)/page/year: 9(6),66,1969

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/m3/6H/24W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962- Volume(issue)/page/year: 9(6),66,1969

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/m3/6H/24W-I

TOXIC EFFECTS :: Liver - other changes Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: ZKMAAX Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1962- Volume(issue)/page/year: 9(6),66,1969

1,3-二氯-2-丁烯安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
36/37/38-20-10

[ 安全声明 (欧洲) ]:
37/39-26

[ 危险品运输编码 ]:
1993

[ WGK德国 ]:
3

[ RTECS号 ]:
EM4760000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29329995

1,3-二氯-2-丁烯合成路线

1,3-二氯-2-丁烯上下游产品

1,3-二氯-2-丁烯上游产品

1,3-二氯-2-丁烯下游产品

1,3-二氯-2-丁烯制备

1.将氯丁二烯与37%盐酸加入压力釜中，加入适量氯化亚铜及氯化铵，在室温反应12h。反应物冷却后分出有机层，减压蒸馏，收集35-40℃（2.66kPa）馏分，得1,3-二氯-2-丁烯。产率58%。

2. 从含有50%二甲苯和0.1%邻苯二酚的氯一二烯溶液中蒸出·2摩尔氯丁二烯，并与4摩尔37%盐酸、50克氯化亚铜和20克氯化按一起置于耐压瓶中，室温下振摇12小时。反应混合物冷却后，分出有机层，在20m m下通过长40厘米的真气夹套分锢柱进进行分锣。在溶温不超过35-40℃时，收集含有少量氯丁二烯和聚合物的较纯的1，3一二氯一2;丁烯，产率约58%。

3. 将500克(3.84摩尔)乙酸乙酸乙醋和和500克苯加入烧瓶中，置冰浴中冷却。慢慢加入700克3.36摩尔)五氯化磷，约2.5小时。然后加入J}}}毫升水，分出有机层。水层用碳酸钠碱化，苯萃取。合并有机溶液，稀氢氧化钠溶液洗涤几次，减压蒸馏得3一氯一2一丁烯酸乙醋粗产品，产率40%，内有23%是E一3一氯一2一丁烯酸乙醋，
取 200克含有Z一3一氯一2一丁烯酸乙醋的蒸锢残余物加1.升50物盐酸回流水解8小时，得到Z一3一氯一2一丁烯酸，产率40%。在盐酸存在下将Z一3一氯一2一T烯酸与乙醇进行南化反应，得到Z一3一氯一2一丁烯酸乙醋，产率80%.

4. 在无水乙醚中28克(0.17摩尔)Z一3一氯一2一丁烯酸乙醋与4.2克(0.111摩尔)氢化铝锉反应得到16.7克Z一3一氯一2一丁烯一1一醇，产率85%
在5℃搅拌下，将27克(0.20摩尔)三氯化磷滴入50克(0.47摩尔)Z一3一氯一2一丁烯一1一醇和9克吡啶中，约1.5小时，然后在室温继续搅拌2小时，得到44克Z一I，3一二氯一2-丁烯，产率75%.

1,3-二氯-2-丁烯海关

[ 海关编码 ]: 2903299090

[ 中文概述 ]:
HS: 2903299090. 其他无环烃的不饱和氯化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903299090 other unsaturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%