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(3-Triphenylmethylaminomethyl)pyridine

(3-Triphenylmethylaminomethyl)pyridine用途

UCL 2077是sAHP 通道的选择性抑制剂 (海马神经元中的IC50 值为 500 nM),对Ca2+通道、动作电位、输入电阻以及超极化后的介质影响很小。UCL 2077也是具有亚型选择性的、癫痫相关的KCNQ通道的阻滞剂。

(3-Triphenylmethylaminomethyl)pyridine名称

[ CAS 号 ]:
918311-87-2

[ 中文名 ]:
UCL 2077

[ 英文名 ]:
UCL 2077

[英文别名 ]:

hms3261b11
hms3269l03
ucl 2077

(3-Triphenylmethylaminomethyl)pyridine生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[ 靶点 ]

sAHP[1].

[参考文献]

[1]. Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502.

[2]. Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.

(3-Triphenylmethylaminomethyl)pyridine物理化学性质

[ 分子式 ]:
C₂₅H₂₂N₂

[ 分子量 ]:
350.46

[ 精确质量 ]:
350.17800

[ PSA ]:
24.92000

[ LogP ]:
5.55420

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C，密封，干燥

(3-Triphenylmethylaminomethyl)pyridineMSDS

详细MSDS(安全技术说明书)

(3-Triphenylmethylaminomethyl)pyridine安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

(3-Triphenylmethylaminomethyl)pyridine文献

Ca2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors.

J. Neurophysiol. 104(4) , 2052-62, (2010)

Thalamic paraventricular nucleus (PVT) neurons exhibit a postburst apamin-resistant slow afterhyperpolarization (sAHP) that is unique to midline thalamus, displays activity dependence, and is abolishe...

Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077).

Mol. Pharmacol. 70(5) , 1494-502, (2006)

The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory. However, its precise role in cell excitability and central nervous system function has not bee...

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