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2-硝基苯甲醚

2-硝基苯甲醚用途

【用途一】
该品用于染料、医药、香料等工业，可用来制造邻氨基苯甲醚、联大茴香胺、色酚AS-OL、大红色基B、直接湖蓝6B、活性溶蓝KD-7G、净洗剂LS等。

2-硝基苯甲醚名称

[ CAS 号 ]:
91-23-6

[ 中文名 ]:
2-硝基苯甲醚

[ 英文名 ]:
nitroanisole

[中文别名 ]:

[英文别名 ]:

2-NITROANISOL
EINECS 202-052-1
2-Nitroanisole
nitroanisole
O-NITROANISOLE
Benzene, 1-methoxy-2-nitro-
Benzene, methoxynitro-
o-methoxynitrobenzene
MFCD00007096
ANISOLE,ORTHO-NITRO

2-硝基苯甲醚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
277.0±0.0 °C at 760 mmHg

[ 熔点 ]:
9-12 °C(lit.)

[ 分子式 ]:
C₇H₇NO₃

[ 分子量 ]:
153.135

[ 闪点 ]:
127.0±21.8 °C

[ 精确质量 ]:
153.042587

[ PSA ]:
55.05000

[ LogP ]:
1.73

[ 外观性状 ]:
淡黄色至微红的液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.543

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.45 g/L (20 ºC)

2-硝基苯甲醚MSDS

2-硝基苯甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8790000

CHEMICAL NAME :: Anisole, o-nitro-

CAS REGISTRY NUMBER :: 91-23-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C7-H7-N-O3

MOLECULAR WEIGHT :: 153.15

WISWESSER LINE NOTATION :: WNR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8960 mg/kg/14D-C

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27300 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - changes in spleen Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2772 mg/kg/14D-C

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16380 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9604 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 173 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 123 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,369,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,369,1996 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,369,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

2-硝基苯甲醚安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H350

[ 警示性声明 ]:
P201-P280-P301 + P312 + P330-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R22;R45

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 2730 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BZ8790000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29093090

2-硝基苯甲醚合成路线

2-硝基苯甲醚上下游产品

2-硝基苯甲醚上游产品

2-硝基苯甲醚下游产品

2-硝基苯甲醚制备

邻硝基氯苯和烧碱、甲醇进行甲氧基化反应得粗品，粗品经蒸馏、洗涤、干燥，得成品。原料消耗定额：邻硝基氯苯1120kg/t、甲醇270kg/t。

精制方法：在无空气存在下反复进行减压蒸馏。

2-硝基苯甲醚海关

[ 海关编码 ]: 2909309090

[ 中文概述 ]:
2909309090 其他芳香醚及其卤化衍生物、磺化、硝化衍生物（包括亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

2-硝基苯甲醚文献

Structure and performance of silica-based monolithic HPLC columns.

J. Sep. Sci. 31(14) , 2551-9, (2008)

Silica-based monolithic columns were prepared for HPLC with systematic variations of the tetramethoxysilane (TMOS) and polyethylene oxide (PEO) content as reactants in a sol-gel process accompanied by...

Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole.

Neuro Endocrinol. Lett. 30 Suppl 1 , 46-51, (2009)

2-Nitrophenol (2-NP) is the major detoxification metabolite of an important industrial pollutant and a potent carcinogen, 2-nitroanisole (2-NA). Characterization of the products of 2-NP metabolism by ...

Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans.

Carcinogenesis 25(5) , 833-40, (2004)

2-Nitroanisole (2-NA) is an important industrial pollutant and a potent bladder carcinogen for rodents. The mechanism of its carcinogenicity was investigated in this study. Here we have used two indep...

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