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N-乙酰神经氨糖酸醛缩酶

N-乙酰神经氨糖酸醛缩酶用途

N-乙酰神经氨酸裂解酶(NAL)是一类醛缩酶,常用于生化研究。N-乙酰神经氨酸裂解酶催化丙酮酸与N-乙酰-d-甘露糖胺(ManNAc)的可逆缩合,生成唾液酸N-乙酰神经氨基酸(Neu5Ac)[1]。

N-乙酰神经氨糖酸醛缩酶名称

[ CAS 号 ]:
9027-60-5

[ 中文名 ]:
N-乙酰神经氨糖酸醛缩酶(微生物)

[ 英文名 ]:
ec 4.1.3.3

[英文别名 ]:

MFCD00131656

N-乙酰神经氨糖酸醛缩酶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Daniels AD, et al. Reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation, and mutagenesis. ACS Chem Biol. 2014 Apr 18;9(4):1025-32.

N-乙酰神经氨糖酸醛缩酶物理化学性质

[ 密度 ]:
1.000 g/cm3

[ 分子式 ]:
C₂₃H₄₂O₅

[ 分子量 ]:
398.583

[ 外观性状 ]:
powder | slightly yellow

[ 储存条件 ]:
−20°C

N-乙酰神经氨糖酸醛缩酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
23-24/25-60-37-26-22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

N-乙酰神经氨糖酸醛缩酶文献

Chemistry, metabolism, and biological functions of sialic acids.

Adv. Carbohydr. Chem. Biochem. 40 , 131, (1982)

Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida.

Biochemistry 52(47) , 8570-9, (2013)

N-Acetylneuraminate lyases (NALs) or sialic acid aldolases catalyze the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac, the most common form of sialic acid) to form pyruvate and N-acetyl...

Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with γ-thialysine by using a chemical mutagenesis strategy.

ChemBioChem. 14(4) , 474-81, (2013)

Chemical modification has been used to introduce the unnatural amino acid γ-thialysine in place of the catalytically important Lys165 in the enzyme N-acetylneuraminic acid lyase (NAL). The Staphylococ...

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