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胶原质

胶原质用途

胶原蛋白是细胞外基质蛋白,在食品、化妆品、制药和生物医学工业中有许多应用。胶原在皮肤、软骨、骨和结缔组织的结构和功能中发挥重要作用[1]。

胶原质名称

[ CAS 号 ]:
9007-34-5

[ 中文名 ]:
胶原蛋白(鱼)

[ 英文名 ]:
Collagen

[中文别名 ]:

去端肽胶原

[英文别名 ]:

MFCD00130825

胶原质生物活性

[ 描述 ]:

胶原蛋白是细胞外基质蛋白,在食品、化妆品、制药和生物医学工业中有许多应用。胶原在皮肤、软骨、骨和结缔组织的结构和功能中发挥重要作用[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Sorushanova A, et al. The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development. Adv Mater. 2019 Jan;31(1):e1801651.

胶原质物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
558.2±60.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₂₄N₄O₄

[ 分子量 ]:
300.354

[ 闪点 ]:
291.4±32.9 °C

[ 精确质量 ]:
300.179749

[ LogP ]:
-0.82

[ 外观性状 ]:
solution

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.604

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 5 mg/mL, hazy, colorless and viscous | It is soluble in water.

胶原质安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
B

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

胶原质制备

1.以牛筋、牛跟腱等为原料，经磷酸氢二钠溶液和KCl溶液抽提，将残留物经水洗、脱水、干燥后得成品。

2.取哺乳动物的胎盘组织切碎洗涤，加入胃蛋白酶和稀甲酸，20℃下水解16～20h。离心除去不溶物胶原蛋白（Ⅰ）型和（Ⅱ）型，溶液中另加胃蛋白酶水解后加入6.0%的氯化钠以析出沉淀。沉淀溶于ph值7.4的三羟甲基-氨基甲烷  盐酸缓冲溶液中，于45℃渗析和变性，加入3mol ·L－1的氯化钠，冷冻离心。上清液渗析后冷冻干燥即为胶原蛋白（Ⅳ）。

胶原质文献

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.

J. Exp. Med. 211(13) , 2549-66, (2014)

DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate throug...

Tissue-specific splice variants of HARE/Stabilin-2 are expressed in bone marrow, lymph node, and spleen.

Biochem. Biophys. Res. Commun. 456(1) , 257-61, (2015)

The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipop...

Gelatin hydrogel as a carrier of recombinant human fibroblast growth factor-2 during rat mandibular distraction.

J. Oral Maxillofac. Surg. 72(10) , 2015-31, (2014)

The aim of the present study was to evaluate the feasibility of a gelatin hydrogel system to enhance recombinant human fibroblast growth factor-2 (rhFGF-2)-induced osteogenic effects during rat mandib...

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胶原质