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3-乙氧酰基苯胺甲磺酸盐

3-乙氧酰基苯胺甲磺酸盐用途

Tricaine methanesulfonate (MS-222) 具有麻醉活性。Tricaine methanesulfonate (MS-222) 常用于固定鱼的标记和运输,以及在入侵过程中抑制感觉系统。

3-乙氧酰基苯胺甲磺酸盐名称

[ CAS 号 ]:
886-86-2

[ 中文名 ]:
3-氨基苯甲酸乙酯甲基磺酸盐

[ 英文名 ]:
Tricaine methanesulfonate

[中文别名 ]:

[英文别名 ]:

Ethyl 3-aminobenzoate methanesulfonate salt
Ethyl 3-aminobenzoate methanesulfonate
Ethyl 3-aminobenzoate methanesulfonate (1:1)
Ethyl m-aminobenzoate methanesulfonate
ethyl 3-aminobenzoate,methanesulfonic acid
Ethyl 3-aminobenzoate methanesulphonate salt
EINECS 212-956-8
MFCD00013176
Tricaine methansulphate
Tricaine mesylate

3-乙氧酰基苯胺甲磺酸盐生物活性

[ 描述 ]:

Tricaine methanesulfonate (MS-222) 具有麻醉活性。Tricaine methanesulfonate (MS-222) 常用于固定鱼的标记和运输,以及在入侵过程中抑制感觉系统。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

粉末状的甲烷磺酸三嗪很容易在空气中传播,并可能对处理人员造成危害[1]。甲基磺酸三胺(TMS)溶液具有光敏性(其颜色随光照而变化),但颜色变化并不一定表示活性显著降低,因此不应使用颜色来衡量降解情况[1]。

[参考文献]

[1]. Kathleen M. Carter, et al. A review of tricaine methanesulfonate for anesthesia of fish. Reviews in Fish Biology and Fisheries volume 21, pages51–59(2011).

3-乙氧酰基苯胺甲磺酸盐物理化学性质

[ 沸点 ]:
305-310

[ 熔点 ]:
146-149 °C(lit.)

[ 分子式 ]:
C₁₀H₁₅NO₅S

[ 分子量 ]:
261.295

[ 闪点 ]:
151.2ºC

[ 精确质量 ]:
261.067108

[ PSA ]:
115.07000

[ LogP ]:
2.61150

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, colorless

3-乙氧酰基苯胺甲磺酸盐MSDS

详细MSDS(安全技术说明书)

3-乙氧酰基苯胺甲磺酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2455000

CHEMICAL NAME :: Benzoic acid, 3-amino-, ethyl ester, methanesulfonate

CAS REGISTRY NUMBER :: 886-86-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H11-N-O2.C-H4-O3-S

MOLECULAR WEIGHT :: 261.32

WISWESSER LINE NOTATION :: ZR CVO2 &WSQ1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03233

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 16,252,1974

3-乙氧酰基苯胺甲磺酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG2455000

[ 海关编码 ]:
2923900090

3-乙氧酰基苯胺甲磺酸盐海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

3-乙氧酰基苯胺甲磺酸盐文献

Denervation impairs regeneration of amputated zebrafish fins.

BMC Dev. Biol. 14(1) , 49, (2015)

Zebrafish are able to regenerate many of its tissues and organs after damage. In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release...

Toll-Like Receptor 9 Alternatively Spliced Isoform Negatively Regulates TLR9 Signaling in Teleost Fish.

PLoS ONE 10 , e0126388, (2015)

Toll-like receptor 9 (TLR9) recognizes and binds unmethylated CpG motifs in DNA, which are found in the genomes of bacteria and DNA viruses. In fish, Tlr9 is highly diverse, with the number of introns...

Molecular characterization of purinergic receptor P2X4 involved in Japanese flounder (Paralichthys olivaceus) innate immune response and its interaction with ATP release channel Pannexin1.

Fish Shellfish Immunol. 47 , 100-9, (2015)

P2X4 receptor (P2X4R) is a member of trimeric ATP-gated receptor channel family. Despite the importance of P2X4R in innate immunity has been addressed in mammals, the immunological significance of P2X...

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