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促肾上腺皮质激素释放因子

促肾上腺皮质激素释放因子用途

Corticotropin-releasing factor (CRF) (human) 能够刺激垂体前叶的促肾上腺皮质激素的合成和分泌。

促肾上腺皮质激素释放因子名称

[ CAS 号 ]:
86784-80-7

[ 中文名 ]:
促肾上腺皮质激素释放因子

[ 英文名 ]:
Corticotropin-Releasing Factor, human, rat

[英文别名 ]:

Human corticotropin-releasing hormone-41
Rat/human corticotropin-releasing factor
Corticorelin acetate
Corticorelin
Human CRF(1-41)
MFCD00213806
SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2
Corticorelin (Human)
Corticotropin-releasing factor (human)

促肾上腺皮质激素释放因子生物活性

[ 描述 ]:

Corticotropin-releasing factor (CRF) (human) 能够刺激垂体前叶的促肾上腺皮质激素的合成和分泌。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

多肽产品

[体外研究]

CRF通过激活AC-cAMP-PKA途径增加II型dlBNST神经元的兴奋性,从而引起疼痛诱导的厌恶反应[1]。

[体内研究]

这一发现与一种机制是一致的,即由于性别偏向的CRF1信号传导,表征应激相关疾病的过量CRF在男性和女性脑中启动不同的细胞过程[2]。 CRF注射食物摄入量(FI),CRF抑制3个月的雄性和雌性动物的FI [3]。

[参考文献]

[1]. Kaneko T et al. Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factorwithin the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion. Eur J Neurosci. 2016 Sep 30.

[2]. Bangasser DA et al. Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling. Mol Psychiatry. 2016 Oct 18.

[3]. Tenk J et al. Acute central effects of corticotropin-releasing factor (CRF) on energy balance: Effects of age and gender. Peptides. 2016 Nov;85:63-72.

[相关活性小分子]

促肾上腺皮质激素释放因子物理化学性质

[ 分子式 ]:
C₂₀₈H₃₄₄N₆₀O₆₃S₂

[ 分子量 ]:
4757.45

[ 储存条件 ]:
−20°C

促肾上腺皮质激素释放因子安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GM7925000

促肾上腺皮质激素释放因子文献

Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP).

Reprod. Biol. Endocrinol. 11 , 30, (2013)

Placental production of corticotrophin releasing hormone (CRH) rises exponentially as pregnancy progresses, and has been linked with the onset of normal and preterm labour. CRH is produced in syncytio...

Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats.

Int. J. Endocrinol. 2010 , 326151, (2010)

Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pitu...

Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy.

Sci. Rep. 6 , 23342, (2016)

In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety of factors have be...

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