7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine

[ 密度 ]:
1.25g/cm3

[ 分子式 ]:
C₁₀H₁₂N₂S₂

[ 分子量 ]:
224.34600

[ 精确质量 ]:
224.04400

[ PSA ]:
67.90000

[ LogP ]:
3.08650

[ 折射率 ]:
1.656

详细MSDS(安全技术说明书)

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

详细合成路线

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Clin. Pharmacol. Ther. 88(3) , 360-8, (2010)

Oltipraz is a potential candidate drug for the treatment of liver fibrosis (LF) and liver cirrhosis (LC). The pharmacokinetics of oltipraz and its major rearranged metabolite (7-methyl-6,8-bis(methylt...

Mol. Pharmacol. 48(1) , 15-20, (1995)

Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication in vitro (ED50 approximately 10 microM), undergoes extensive metabolism in vivo. Most of the orally administered drug undergoe...

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