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盐酸托莫西汀

盐酸托莫西汀用途

Atomoxetine(LY 139603; Tomoxetine)盐酸盐是去甲肾上腺素重吸收抑制剂,与人NET,SERT和DAT的放射性配体结合的Ki分别为5,77和1451 nM。

盐酸托莫西汀名称

[ CAS 号 ]:
82248-59-7

[ 中文名 ]:
盐酸托莫西汀

[ 英文名 ]:
Atomoxetine Hydrochloride

[中文别名 ]:

[英文别名 ]:

Atomoxetine HCL
MFCD06410992
Atomoxetine hydrochloride
EINECS 200-659-6
Atomoxetine (hydrochloride)

盐酸托莫西汀生物活性

[ 描述 ]:

Atomoxetine(LY 139603; Tomoxetine)盐酸盐是去甲肾上腺素重吸收抑制剂,与人NET,SERT和DAT的放射性配体结合的Ki分别为5,77和1451 nM。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. McAfee AT, Landon J, Jones M, et al. A cohort study of the risk of seizures in a pediatric population treated with atomoxetine or stimulant medications. Pharmacoepidemiol Drug Saf. 2012 Dec 26.

[2]. Turner M, Wilding E, Cassidy E, Dommett EJ. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2012 Dec 22;243C:28-37.

[3]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 N

[4]. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther. 1997 Dec;283(3):1305-22.

[5]. Atomoxetine

[相关活性小分子]

盐酸托莫西汀物理化学性质

[ 沸点 ]:
389ºC at 760 mmHg

[ 熔点 ]:
167-169ºC

[ 分子式 ]:
C₁₇H₂₂ClNO

[ 分子量 ]:
291.816

[ 闪点 ]:
164.1ºC

[ 精确质量 ]:
291.138977

[ PSA ]:
21.26000

[ LogP ]:
4.91750

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

盐酸托莫西汀MSDS

盐酸托莫西汀安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK德国 ]:
3

[ 海关编码 ]:
2922299090

盐酸托莫西汀合成路线

盐酸托莫西汀上下游产品

盐酸托莫西汀上游产品

盐酸托莫西汀下游产品

盐酸托莫西汀海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

盐酸托莫西汀文献

Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.

J. Neurosci. 35(1) , 161-9, (2015)

Positive social interactions during the juvenile and adolescent phases of life, in the form of social play behavior, are important for social and cognitive development. However, the neural mechanisms ...

Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice.

J. Pharmacol. Exp. Ther. 351(3) , 663-73, (2014)

Skeletal muscle atrophy remains a clinical problem in numerous pathologic conditions. β2-Adrenergic receptor agonists, such as formoterol, can induce mitochondrial biogenesis (MB) to prevent such atro...

Current pharmacotherapy of attention deficit hyperactivity disorder.

Drugs Today (Barc) 49(10) , 647-65, (2013)

Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder in children and adults characterized by a persistent pattern of impulsiveness, inattention and hyperactivity...

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盐酸托莫西汀相关知识

盐酸托莫西汀说明书-盐酸托莫西汀胶囊的副作用

2018-12-27 14:16:40

导读：盐酸托莫西汀是一种高度选择性去甲肾上腺素再摄取抑制剂，与其他神经递质亲和力极低。治疗多动症的作用机制是，其可以提高突出间隙中的去甲肾上腺素水平，增加正相传输，并且可提高前额叶皮质的多巴胺水平，同时不增加纹状体部位的多巴胺活动，从而不会诱导抽动症状或增加运动障碍。盐酸托莫西汀胶囊一般不建议长期...