1-氨基蒽醌

1-氨基蒽醌用途

【用途一】
用于制分散、活性、还原染料
【用途二】
用作分析试剂，也用于有机合成
【用途三】
重要的染料中间体。可用于生产还原咔叽2G、还原红棕R、还原橄榄绿B、橄榄T、橄榄R 还原灰M、分散红3B 以及活性艳蓝KN-R、活性艳蓝M-BR。
【用途四】
用于制蒽醌染料等。重要的染料中间体。可用于生产还原咔叽2G、还原红棕R、还原橄榄绿B、橄榄T、橄榄R 还原灰M、分散红3B 以及活性艳蓝KN-R、活性艳蓝M-BR。

1-氨基蒽醌名称

[ CAS 号 ]:
82-45-1

[ 中文名 ]:
1-氨基蒽醌

[ 英文名 ]:
Fast Red AL

[中文别名 ]:

[英文别名 ]:

1-Amino anthraquinone
AMINO-9,10-ANTHRACENEDIONE
Fast Red AL
aminoanthraquinone
EINECS 201-423-5
a-Aminoanthraquinone
α-Aminoanthraquinone
a-Anthraquinonylamine
MFCD00001213
1-Amino-9,10-anthraquinone

1-氨基蒽醌物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
464.9±34.0 °C at 760 mmHg

[ 熔点 ]:
253-255 °C(lit.)

[ 分子式 ]:
C₁₄H₉NO₂

[ 分子量 ]:
223.227

[ 闪点 ]:
235.0±25.7 °C

[ 精确质量 ]:
223.063324

[ PSA ]:
60.16000

[ LogP ]:
3.35

[ 外观性状 ]:
棕色至红色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.708

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents.

1-氨基蒽醌MSDS

详细MSDS(安全技术说明书)

1-氨基蒽醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB5075000

CHEMICAL NAME :: Anthraquinone, 1-amino-

CAS REGISTRY NUMBER :: 82-45-1

BEILSTEIN REFERENCE NO. :: 0396360

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C14-H9-N-O2

MOLECULAR WEIGHT :: 223.24

WISWESSER LINE NOTATION :: L C666 BV IVJ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6026 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/2W-I

TOXIC EFFECTS :: Behavioral - excitement Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/m3/17W-I

TOXIC EFFECTS :: Behavioral - excitement Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 14 gm/kg/2W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Peripheral Nerve and Sensation - structural change in nerve or sheath

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3000 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

REFERENCE :: ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 5,355,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993

1-氨基蒽醌安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
CB5075000

[ 海关编码 ]:
29223900

1-氨基蒽醌合成路线

详细合成路线

1-氨基蒽醌上下游产品

1-氨基蒽醌上游产品

1-氨基蒽醌下游产品

1-氨基蒽醌制备

１．硝化还原法　蒽醌经混酸硝化得硝基蒽醌，反应产物过滤并用热水洗至中性后，用亚硫酸钠精制。其中２-硝基蒽醌与亚硫酸钠生成易溶于水的蒽醌-２-磺酸钠，过滤后洗涤除去之。所得１-硝基蒽醌用硫化钠还原得１-氨基蒽醌粗品，经加碱液、保险粉精制除去二氨基蒽醌后再用氧气氧化、过滤、干燥，得成品。

２．蒽醌磺酸盐氨解法　蒽醌与发烟硫酸在硫酸汞存在下反应，生成蒽醌-１-磺酸，经氨水中和，再置换成钠盐，然后在间硝基苯磺酸钠催化下氨解生成１-氨基蒽醌，精制后得成品。

1-氨基蒽醌海关

[ 海关编码 ]: 29223900

1-氨基蒽醌文献

[A routine analytical method for carcinogenic isomers in commercial 1-aminoanthraquinone and 1-aminoanthracene by high performance liquid chromatography].

Sangyo. Igaku. 28(2) , 124-5, (1986)

Radiosensitization by dimethylbenzanthracene, diphenylcyclopropenone and aminoanthraquinones.

J. Toxicol. Sci. 20(2) , 149-54, (1995)

Radiosensitization of mice by dimethylbenzanthracene, diphenylcyclopropenone and aminoanthraquinones was investigated in a model where survival time after lethal radiation was scored. Survival time wa...

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.

J. Med. Chem. 53 , 1799-809, (2010)

The recent progress in crystallography of G-protein coupled receptors opens an unprecedented venue for structure-based GPCR drug discovery. To test efficiency of the structure-based approach, we perfo...

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