二甲苯麝香

二甲苯麝香用途

用途一：用作皂用香精、化妆香精定香剂
用途二：GB 2760--1996规定为允许使用的香料。
用途三：价格低廉，广泛用于低档的各种类型的香精，如日用化学品和廉价化妆品用香精，作为定香剂和修饰剂，亦广泛用于香皂、香波、香粉香精中。玫瑰香型中用之甚佳。还宜用作松木香型的主要定香剂。香皂香精中用量可达用3%-6%。
用途四：该品具有强烈的麝香的气味，是人造麝香中较低档的品种，但价廉易得，广泛用于化妆品香精和皂用香精中作为定香剂。在肥皂中用量为0.03-0.15%，去垢剂中0.003-0.015%，香水中0.2-0.5%，香脂和洗液中为0.01-0.05%。二甲苯麝香同时也作为很多中药膏贴剂的透皮剂使用，增加药物的表皮吸收，且有镇静、镇痛的作用，虽然本品称为人造麝香，但是他是单一的化合物，不同于麝香属于天然的多组分混合物。用麝香制成的含有药物中含有普拉雄酮，而被列为兴奋剂，在使用上有一定的限制，而二甲苯麝香，这好避开了这一限制得到一些业内人士的重视。同时用于化妆品、香皂、洗涤剂、熏香用品香精

二甲苯麝香名称

[ CAS 号 ]:
81-15-2

[ 中文名 ]:
二甲苯麝香

[ 英文名 ]:
Musk Xylol

[中文别名 ]:

[英文别名 ]:

xylenemusk
MUSK XYLENE
MOSCHUS XYLOL
EINECS 201-329-4
1-t-butyl-3,5-dimethyl-2,4,6-trinitrobenzene
MUSK XLYENE
2,4,6-trinitro-5-tert-butyl-1,3-dimethylbenzene
MFCD00024270
musk xylol
1-tert-butyl-3,5-dimethyl-2,4,6-trinitrobenzene

二甲苯麝香物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
392.3±42.0 °C at 760 mmHg

[ 熔点 ]:
235.4°C

[ 分子式 ]:
C₁₂H₁₅N₃O₆

[ 分子量 ]:
297.264

[ 闪点 ]:
174.2±20.7 °C

[ 精确质量 ]:
297.096100

[ PSA ]:
137.46000

[ LogP ]:
3.83

[ 外观性状 ]:
淡黄色针状粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.573

[ 储存条件 ]:
2-8°C

二甲苯麝香毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ7210000

CHEMICAL NAME :: Benzene, 1-(1,1-dimethylethyl)-3,5-dimethyl-2,4,6-trinitro-

CAS REGISTRY NUMBER :: 81-15-2

BEILSTEIN REFERENCE NO. :: 2015910

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C12-H15-N3-O6

MOLECULAR WEIGHT :: 297.30

WISWESSER LINE NOTATION :: WNR B1 F1 CNW ENW DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,881,1975 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 26,656,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,581,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 26,656,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5040 mg/kg/14D-C

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - ulceration or bleeding from stomach Related to Chronic Data - death

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (108),89,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21420 mg/kg/17W-C

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (108),89,1990 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 gm/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - tumors

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,581,1990 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,477,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,477,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,477,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83002 No. of Facilities: 463 (estimated) No. of Industries: 7 No. of Occupations: 29 No. of Employees: 89788 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83002 No. of Facilities: 9459 (estimated) No. of Industries: 81 No. of Occupations: 86 No. of Employees: 134413 (estimated) No. of Female Employees: 48955 (estimated)

二甲苯麝香安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
E,Xn,N,F

[ 风险声明 (欧洲) ]:
R2

[ 安全声明 (欧洲) ]:
S36/37-S46-S60-S61-S16

[ 危险品运输编码 ]:
2956

二甲苯麝香合成路线

详细合成路线

二甲苯麝香上下游产品

二甲苯麝香上游产品

二甲苯麝香下游产品

二甲苯麝香制备

氯代叔丁烷在氯化铝存在下，与间二甲苯作用生成1,3-二甲苯-5-叔丁基苯，再用浓硝酸硝化而制得。