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二甲基硅油

二甲基硅油用途

二甲基硅氧烷是一种口服活性消泡剂。二甲基硅氧烷可降低胃肠道中气泡的表面张力,使其通过呕吐、呼气或吸收而排出到血液中。二甲基硅氧烷在肠胃气胀和绞痛方面有潜在的应用[1]。

二甲基硅油名称

[ CAS 号 ]:
8050-81-5

[ 中文名 ]:
二甲基硅油350

[ 英文名 ]:
Simethicone

[英文别名 ]:

4-trimethylsilylstyrene
poly(3-hexylthiophene)
poly(4-trimethylsilylstyrene)
Simethicone
p-(Trimethylsilyl)styrene
trimethyl-(4-vinyl-phenyl)-silane
3-(Hex-1-yl)thiophene
poly(acrylamide)
3-hexyltiophene

二甲基硅油生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体内研究]

二甲基硅氧烷(200 mg/kg口服；单剂量) 在大鼠中具有肠胃调节功能[2]。二甲基硅氧烷(20 mg/kg口服；单剂量) 在兔子中显示出空肠调节作用[3]。动物模型：雌性成年Wistar大鼠(200-250 g)[2]。剂量：50、100和200 mg/kg。给药：经口灌胃；单剂量。结果：结肠通透性和超敏反应得到改善(200mg/kg)。动物模型：成年新西兰白(NZW)兔[3]。剂量：20 mg/kg。给药：经口灌胃；单剂量。结果：改善了空肠的图像质量评分,而不影响左肾、右肾和胆囊。

[参考文献]

[1]. Voepel-Lewis TD, et al. Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants. J Clin Anesth. 1998 Mar;10(2):91-4.

[2]. Bueno L, et al. Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association. J Pharm Pharmacol. 2013 Apr;65(4):567-73.

[3]. da Silva KG, et al. Influence of simethicone and fasting on the quality of abdominal ultrasonography in New Zealand White rabbits. Acta Vet Scand. 2017 Jul 17;59(1):48.

二甲基硅油物理化学性质

[ 密度 ]:
1 g/mL at 20ºC

[ 沸点 ]:
96.5ºC at 760 mmHg

[ 分子式 ]:
C₆H₁₈O₄Si₃

[ 分子量 ]:
238.46100

[ 闪点 ]:
6.3ºC

[ 精确质量 ]:
238.05100

[ PSA ]:
52.60000

[ LogP ]:
1.56770

[ 外观性状 ]:
emulsion | Colorless

[ 蒸汽压 ]:
5 mm Hg ( 20 °C)

[ 折射率 ]:
n20/D 1.406

[ 储存条件 ]:
room temp

[ 水溶解性 ]:
Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.

二甲基硅油MSDS

详细MSDS(安全技术说明书)

二甲基硅油毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VW6200000

CHEMICAL NAME :: Simethicone

CAS REGISTRY NUMBER :: 8050-81-5

LAST UPDATED :: 199504

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: AMSGAO AMA Archives of Surgery. (Chicago, IL) V.61-80, 1950-60. For publisher information, see ARSUAX. Volume(issue)/page/year: 78,220,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes

REFERENCE :: AMSGAO AMA Archives of Surgery. (Chicago, IL) V.61-80, 1950-60. For publisher information, see ARSUAX. Volume(issue)/page/year: 78,220,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4515 No. of Facilities: 1163 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 90654 (estimated) No. of Female Employees: 75193 (estimated)

二甲基硅油安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37-20

[ 安全声明 (欧洲) ]:
26-36-23

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TQ2690000

二甲基硅油制备

采用碱法和酸法。碱法是以二甲基环硅氧烷为原料,在六甲基二硅醚止链剂和四甲基氢氧化铵催化剂存在下,进行调聚反应而得。酸法是以硅橡胶的低沸物为原料,在六甲基二硅醚止链剂和浓硫酸催化剂存在下,进行调聚反应,然后经除酸、洗涤、脱色、抽滤而得。

二甲基硅油文献

The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea.

Aliment. Pharmacol. Ther. 36(1) , 64-73, (2012)

Loperamide (LOP) is an anti-diarrhoeal agent which is thought to act largely by slowing transit with an uncertain effect on the fluid content of the small and large bowel in humans. Adding simethicone...

Commentary: low-volume bowel preparation for colonoscopy - authors' reply.

Aliment. Pharmacol. Ther. 36(10) , 989, (2012)

Commentary: low-volume bowel preparation for colonoscopy.

Aliment. Pharmacol. Ther. 36(10) , 988-9, (2012)

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