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三七皂苷R1

三七皂苷R1用途

三七皂苷R1 (Notoginsenoside R1) 三七的主要活性成分,据报道有神经保护、抗高血压的作用。

三七皂苷R1名称

[ CAS 号 ]:
80418-24-2

[ 中文名 ]:
三七皂甙 R1

[ 英文名 ]:
Notoginsenoside R1

[中文别名 ]:

[英文别名 ]:

notoginsenoside Rh1
Sanchinoside R1
NOTOGINSENOSIDE
notogisenoside R1
Notoginsenoside R1
ginsenoside-Rg2
NotoginsenosideR1

三七皂苷R1生物活性

[ 描述 ]:

三七皂苷R1 (Notoginsenoside R1) 三七的主要活性成分,据报道有神经保护、抗高血压的作用。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> β淀粉样蛋白

研究领域 >> 其他

天然产物 >> 萜类化合物和糖苷

[参考文献]

[1]. Yang Y, et al. Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457. Int J Clin Exp Pathol. 2015 Mar 1;8(3):2700-9.

[2]. Li Zhi, et al. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer&aposs Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzh

[3]. PU Xian-hong, et al. The Effect of Notoginsenoside R1 on TGF-β1/smad3 Signal Pathway in Hepatic Fibrosis Rats. Progress in Modern Biomedicine, 2015-04

[相关活性小分子]

三七皂苷R1物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
1010.5±65.0 °C at 760 mmHg

[ 熔点 ]:
218 °C

[ 分子式 ]:
C₄₇H₈₀O₁₈

[ 分子量 ]:
933.127

[ 闪点 ]:
564.9±34.3 °C

[ 精确质量 ]:
932.534485

[ PSA ]:
298.14000

[ LogP ]:
4.42

[ 外观性状 ]:
white to off-white

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.614

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble1mg/mL, clear, colorless

三七皂苷R1安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
29389090

三七皂苷R1文献

Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress.

J. Agric. Food Chem. 63(9) , 2413-22, (2015)

The aim of present study was to evaluate the effects of Panax notoginseng saponins (PNS) against acute ethanol-induced liver injury and further to elucidate its probable mechanisms. Mice were treated ...

A comparative study of using in-line near-infrared spectra, ultraviolet spectra and fused spectra to monitor Panax notoginseng adsorption process.

J. Pharm. Biomed. Anal. 102 , 78-84, (2014)

The step of enriching and purifying saponins by macroporous resin column chromatography is closely related to the safety and efficacy of Panax notoginseng products during their manufacturing processes...

Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis.

J. Pharm. Biomed. Anal. 99 , 8-15, (2014)

American ginseng (Panax quinquefolius) is originally grown in North America. Due to price difference and supply shortage, American ginseng recently has been cultivated in northern China. Further, in t...

更多文献

三七皂苷R1

三七皂苷R1用途

三七皂苷R1名称

三七皂苷R1生物活性

三七皂苷R1物理化学性质

三七皂苷R1安全信息

三七皂苷R1文献

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