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对甲苯磺酸乙酯

对甲苯磺酸乙酯用途

4-甲基苯磺酸乙酯(对甲苯磺酸乙酯)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

对甲苯磺酸乙酯名称

[ CAS 号 ]:
80-40-0

[ 中文名 ]:
对甲苯磺酸乙酯

[ 英文名 ]:
Ethyl 4-methylbenzenesulfonate

[中文别名 ]:

[英文别名 ]:

Benzenesulfonic acid, 4-methyl-, ethyl ester
ethyl p-toluenesulfonate
EINECS 201-276-7
Ethyl 4-methylbenzenesulfonate
MFCD00009100

对甲苯磺酸乙酯生物活性

[ 描述 ]:

4-甲基苯磺酸乙酯(对甲苯磺酸乙酯)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

对甲苯磺酸乙酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
306.2±11.0 °C at 760 mmHg

[ 熔点 ]:
29-33 °C(lit.)

[ 分子式 ]:
C₉H₁₂O₃S

[ 分子量 ]:
200.25

[ 闪点 ]:
157.8±0.0 °C

[ 精确质量 ]:
200.050720

[ PSA ]:
51.75000

[ LogP ]:
1.83

[ 外观性状 ]:
透明无色至褐色液体在熔点后

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.513

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

[ 水溶解性 ]:
Insoluble

对甲苯磺酸乙酯MSDS

对甲苯磺酸乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT6825000

CHEMICAL NAME :: p-Toluenesulfonic acid, ethyl ester

CAS REGISTRY NUMBER :: 80-40-0

BEILSTEIN REFERENCE NO. :: 0611213

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C9-H12-O3-S

MOLECULAR WEIGHT :: 200.27

WISWESSER LINE NOTATION :: 2OSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3250 mg/kg/65W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 500 ug/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 1,323,1980

对甲苯磺酸乙酯安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R40

[ 安全声明 (欧洲) ]:
S26-S45-S36/37/39

[ 危险品运输编码 ]:
UN2811

[ WGK德国 ]:
3

[ RTECS号 ]:
XT6825000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29041000

对甲苯磺酸乙酯合成路线

对甲苯磺酸乙酯上下游产品

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对甲苯磺酸乙酯制备

由对甲苯磺酰氯与乙醇酯化而得。将对甲苯磺酰氯加入无水乙醇中，微热溶解。于10-12℃下开始慢慢滴加氢氧化钠溶液，温度不超过15℃，每隔半小时测定1次pH值，保持9.3-9.7反应4h。加冰水，冷却至0℃，析出结晶。过滤，干燥得对甲苯磺酸乙酯。

对甲苯磺酸乙酯海关

[ 海关编码 ]: 29041000

对甲苯磺酸乙酯文献

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PET with selective adenosine 2A receptor (A2A) radiotracers can be used to study a variety of neurodegenerative and neuropsychiatric disorders in vivo and to support drug-discovery studies targeting A...

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J. Pharm. Biomed. Anal. 45(3) , 472-9, (2007)

A simple, reliable and fast procedure for the simultaneous determination of residues of some common alkylating agents (AAs), such as mesylates, besylates, tosylates and sulfates, employed in drug synt...

Determination of methyl and ethyl esters of methanesulfonic, benzenesulfonic and p-toluenesulfonic acids in active pharmaceutical ingredients by solid-phase microextraction (SPME) coupled to GC/SIM-MS.

J. Pharm. Biomed. Anal. 39(3-4) , 477-85, (2005)

The development, optimization and validation of an extraction method for methyl and ethyl esters of various sulfonic acids is presented. The extraction and determination of these esters in active phar...

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