舍曲林
舍曲林名称
[ CAS 号 ]:
79617-96-2
[ 中文名 ]:
舍曲林
[ 英文名 ]:
Sertraline
[中文别名 ]:
[英文别名 ]:
- Zoloft
- Sertralina
- Sertraline
- Tert-butyl5,6-dihydropyridine-1(2H)-carboxylate
- Apo-Sertraline
- MFCD00865372
- (+)-Sertraline
- Sertralinum
- Lustral
舍曲林物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
416.3±45.0 °C at 760 mmHg
[ 熔点 ]:
188-190 °C(lit.)
[ 分子式 ]:
C17H17Cl2N
[ 分子量 ]:
306.230
[ 闪点 ]:
205.6±28.7 °C
[ 精确质量 ]:
305.073792
[ PSA ]:
12.03000
[ LogP ]:
4.81
[ 外观性状 ]:
白色至灰白色粉末
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.621
[ 储存条件 ]:
2-8°C
舍曲林毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QJ0400000
- CHEMICAL NAME :
- 1-Naphthalenamine, 1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-
- CAS REGISTRY NUMBER :
- 79617-96-2
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C17-H17-Cl2-N
- MOLECULAR WEIGHT :
- 306.25
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 63 mg/kg/10W-I
- TOXIC EFFECTS :
- Blood - tumors
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 153,443,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 70 mg/kg/7W-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 153,732,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 28 mg/kg/4W-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 72,446,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 10500 ug/kg/3W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Endocrine - antidiuresis Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 123,811,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 5714 ug/kg/9D-I
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement
- REFERENCE :
- JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 55,316,1994
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3571 mg/kg/5D-I
- TOXIC EFFECTS :
- Endocrine - antidiuresis Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 152,809,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 6 mg/kg/4D-I
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Endocrine - antidiuresis Nutritional and Gross Metabolic - other changes
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 152,809,1995
舍曲林安全信息
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36
[ WGK德国 ]:
3
舍曲林合成路线
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舍曲林上游产品
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